摘要
目的探讨溶质载体蛋白(SLC)及其受体趋化因子受体7(CCR7)与I期非小细胞肺癌(NSCLC)淋巴结微转移的相关性。方法选取2019年1月~2020年3月于我院就诊的I期NSCLC患者127例为研究对象,按照淋巴结微转移情况分为对照组92例和转移组35例,所有患者入院后均通过根治术切除病灶,通过免疫组化方式检测病灶中SLC7A11及CCR7含量,并收集患者临床资料、实验室检查资料及影像学检查资料。通过Logistic回归分析评价SLC7A11及CCR7与淋巴结微转移之间的关系。最后通过建立ROC曲线分析两者及其联合检测对NSCLC患者微淋巴结转移的预测价值。结果两组患者SLC7A11及CCR7表达水平存在显著差异(P<0.05)。转移组患者病灶直径、支气管受累及TLG显著高于对照组(P<0.05)。病灶直径(OR=49.254,95%CI=11.062~507.604)是影响NSCLC淋巴结微转移的独立危险因素(P<0.05)。SLC7A11(OR=8.622)及CCR7(OR=8.709)表达水平是影响NSCLC淋巴结微转移的独立因素(P<0.05)。SLC7A11、CCR7及联合诊断对NSCLC淋巴结微转移具有较好的检测价值(均P<0.05)。联合检测特异度显著高于SLC7A11及CCR7单独检测(χ^(2)=7.292,15.125;均P<0.01)。结论SLC家族的中SLC7A11及其受体CCR7与NSCLC患者微淋巴结转移显著相关。
Objective To explore the relationship between solute carrier protein(SLC)and its receptor chemokine receptor 7(CCR7)and lymph node micrometastasis in stage I non-small cell lung cancer(NSCLC).Methods 127 patients with stage I NSCLC who were treated in our hospital from January 2019 to March 2020 were selected.They were divided into a control group(n=92)and a metastasis group(n=35),according to the micrometastasis of lymph nodes.All the lesions were removed by radical operation,and then the contents of SLC7A11 and CCR7 in the lesions were detected by immunohistochemistry,and the clinical data,laboratory examination data and imaging examination data of patients were collected.Then logistic regression analysis was used to evaluate the relationship between SLC7A11 and CCR7 and lymph node micrometastasis.Finally,the ROC curve was established to analyze the predictive value of the two and their combined detection for micro-lymph node metastasis in NSCLC patients.Results The expression levels of SLC7A11 and CCR7 in the two groups were significantly different(P<0.05).The diameter of lesions,bronchial involvement and TLG in the metastatic group were significantly higher than those in the control group(P<0.05).The diameter of the lesion(OR=49.254,95%CI=11.062-507.604)is an independent risk factor affecting the micrometastasis of NSCLC lymph nodes(P<0.05).The expression levels of SLC7A11(OR=8.622)and CCR7(OR=8.709)were independent factors affecting the micrometastasis of NSCLC lymph nodes(P<0.05).SLC7A11,CCR7 and combined diagnosis have good detection value for NSCLC lymph node micrometastasis(all P<0.05).The specificity of the combined detection was significantly higher than that of SLC7A11 and CCR7 alone(χ^(2)=7.292,15.125;both P<0.01).Conclusion SLC7A11 and its receptor CCR7 in the SLC family are significantly associated with micro-lymph node metastasis in NSCLC patients.
作者
裴艳志
聂美楠
姜腾蛟
王晓强
李春磊
路通
朱晓峰
邹志田
PEI Yanzhi;NIE Meinan;JIANG Tengjiao;WANG Xiaoqiang;LI Chunlei;LU Tong;ZHU Xiaofeng;ZOU Zhitian(Department of Thoracic Surgery, The First Affiliated Hospital of Jiamusi University, Jiamusi 154007, Heilongjiang, China;Department of Pathology, The First Affiliated Hospital of Jiamusi University, Jiamusi 154007, Heilongjiang, China)
出处
《西部医学》
2022年第1期88-93,共6页
Medical Journal of West China
基金
黑龙江省卫生计生委科研课题(2017-379)。
关键词
非小细胞肺癌
溶质载体蛋白
趋化因子受体7
淋巴结微转移
Non-small cell lung cancer
Solute carrier protein
Chemokine receptor 7
Lymph node micrometastasis
