摘要
目的:探讨沙库巴曲缬沙坦对急性前壁STEMI患者NT-proBNP浓度、心功能及心血管事件的影响。方法:将2018年1月—2021年1月在我院治疗的200例急性前壁STEMI患者按入院奇偶数字排序法分为对照组98例与观察组102例。在常规治疗基础上,对照组加用马来酸依那普利片,观察组加用沙库巴曲缬沙坦钠片,比较两组NT-proBNP浓度、心功能指标以及心血管不良事件发生情况。结果:治疗1、3个月后,观察组NT-proBNP浓度低于对照组,差异有统计学意义(P<0.05);观察组LVEF、CI指标高于对照组,LVEDD、左室梗死面积低于对照组,差异有统计学意义(P<0.05)。随访3个月,观察组心血管不良事件总发生率低于对照组,差异有统计学意义(P<0.05)。结论:对于急性前壁STEMI患者应用沙库巴曲缬沙坦治疗,能降低患者NT-proBNP浓度,可改善患者心功能,减少心血管不良事件的发生,具有积极临床应用意义。
Objective:To explore the effects of sacubitril and valsartan on the concentration of NT-proBNP,heart function and cardiovascular events in patients with acute anterior STEMI.Methods:A total of 200 patients with acute anterior wall STEMI treated in our hospital from January 2018 to January 2021 were divided into the control group(n=98)and the observation group(n=102)according to the parity number ranking method.On the basis of routine treatment,the control group was treated with enalapril maleate tablets,and the observation group was treated with sacubitri valsartan sodium tablets.The concentration of NT-proBNP,cardiac function indexes and adverse cardiovascular events were compared between the two groups.Results:After 1 and 3 months of treatment,the concentration of NT-proBNP in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).LVEF and CI in the observation group were higher than those in the control group,LVEDD and left ventricular infarction area were lower than those in the control group,the difference was statistically significant(P<0.05).After 3 months of follow-up,the total incidence of cardiovascular adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:For patients with acute anterior wall STEMI,the application of sacubitril and valsartan can reduce the concentration of NT-proBNP in patients,improve the cardiac function of patients,and reduce the occurrence of adverse cardiovascular events,which has positive clinical application significance.
作者
闫记生
胡法国
YAN Jisheng;HU Faguo(Department of Cardiovascular Medicine,Seventh People’s Hospital of Zhengzhou,Zhengzhou 450000,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2021年第6期853-856,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
沙库巴曲缬沙坦
急性前壁STEMI
NT-proBNP浓度
心功能
心血管事件
Sacubitril and Valsartan
ST Segment-elevated Myocardial Infarction
N-terminal B-type Natriuretic Peptide
Heart Function
Cardiovascular Events
