摘要
胃癌是最常见的消化道恶性肿瘤之一,胃癌的发展经历了多个不同的病变过程,包括慢性非萎缩性胃炎-慢性萎缩性胃炎-肠上皮化生-异型增生-肠型胃腺癌。而胃黏膜化生作为重要的胃癌癌前病变之一,包括肠上皮化生和解痉多肽表达性化生。早期胃癌的5年生存率明显高于晚期胃癌,因此,提高对胃癌前病变的认识,深入研究其发生、发展及癌变的分子机制,对胃癌早期诊断及治疗至关重要,且可为早期胃癌诊治研究提供可靠的理论依据及分子靶点。
Gastric cancer is one of the most common malignant tumors of the digestive system.The development of gastric cancer experiences several different pathological processes,including chronic non-atrophic gastritis-chronic atrophic gastritis-intestinal metaplasia-dysplasia-intestinal gastric adenocarcinoma.Metaplasia occurring in the gastric mucosa as an important gastric precancerous lesion,includes intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia.The 5-year survival rate of early gastric cancer is significantly higher than that of advanced gastric cancer.Therefore,it will be of great importance for the early diagnosis and treatment of gastric cancer to improve the understanding of gastric precancerous lesions and explore the molecular mechanism of their occurrence,development and canceration.which can also provide reliable theoretical basis and molecular target for the study of diagnosis and treatment of early gastric cancer.
作者
陈科
安方梅
占强
CHEN Ke;AN Fangmei;ZHAN Qiang(Department of Gastroenterology,the Affiliated Wuxi People′s Hospital of Nanjing Medical University,Wuxi 214023,China)
出处
《医学综述》
CAS
2021年第24期4826-4831,共6页
Medical Recapitulate
基金
无锡市科技发展资金项目(N20201004)
无锡市卫生健康委科研项目(Z201903)
无锡市“双百”中青年医疗卫生拔尖人才培养计划(BJ2020003)。
关键词
胃癌
肠上皮化生
解痉多肽表达性化生
信号通路
Gastric cancer
Intestinal metaplasia
Spasmolytic polypeptide-expressing metaplasia
Signaling pathways
