摘要
妊娠期高血压疾病(HDP)在孕前肥胖人群中的发病率显著升高,目前其具体机制尚不明确。肥胖是HDP的重要独立危险因素,并与肠道菌群紊乱密切相关。肠道菌群紊乱常导致机体短链脂肪酸(SCFA)水平失衡,影响SCFA发挥抑制炎症反应、调节机体代谢及血压等正常的生理功能,进而诱发并加重HDP的病理生理过程。因此,肥胖人群中HDP高发的现象可能与肠道菌群紊乱导致的机体SCFA水平失衡有关,通过调节肠道菌群等维持机体正常SCFA水平是预防HDP的可行手段之一。
Hypertensive disorders of pregnancy(HDP)has a significantly higher incidence in people who are obese before pregnancy,and the specific mechanisms are not well defined.As an important independent risk factor for HDP,obesity is closely related to dysfunction of gut microbiota.Dysfunction of gut microbiota often leads to the imbalance of short-chain fatty acid(SCFA),which affects the normal physiological functions of SCFA,such as inhibiting inflammatory response,regulating body metabolism and blood pressure,and then induces and aggravates the pathophysiological process of HDP.Therefore,the high incidence of HDP in obese people may be related to the imbalance of SCFA level caused by intestinal flora disorder,and maintaining normal SCFA levels in the body by means such as regulating the intestinal flora is one of the feasible means to prevent HDP.
作者
宋伟
李光辉
SONG Wei;LI Guanghui(Department of Obstetrics,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)
出处
《医学综述》
CAS
2021年第24期4805-4810,共6页
Medical Recapitulate
基金
北京市“登峰”人才培养计划(DFL20191402)
北京市自然科学基金-三元联合资助项目(S160001)。
关键词
妊娠期高血压疾病
肥胖
肠道菌群紊乱
短链脂肪酸
炎症反应
能量代谢
肾素-血管紧张素-醛固酮系统
Hypertensive disorders of pregnancy
Obesity
Dysfunction of gut microbiota
Short-chain fatty acid
Inflammatory reaction
Energy metabolism
Renin-angiotensin-aldosterone system
