摘要
目的评估2型糖尿病(T2DM)患者一级亲属颈动脉弹性功能。方法连续入组2020年10月至2021年5月在河南省人民医院内分泌科进行诊疗的T2DM患者一级亲属90例为家族史阳性者纳入研究。根据父母糖尿病史将其分为3组:父亲家族史阳性(F)组31例、母亲家族史阳性(M)组31例和父母家族史阳性(B)组28例。另同期选择30例年龄、性别和体质指数相匹配且父母均无糖尿病、高血压、高血脂、冠心病病史及家族史的健康志愿者作为对照组。采用全息血管内-中膜厚度测量(RIMT)和全息血管硬度分析(R-VQS)技术测量颈动脉内-中膜厚度(IMT)、管径变化值(Dist)、血管收缩期管径(Diam)、硬度指数(HC)和脉搏波传导速度(PWV),比较各组间上述参数差异。结果①四组间颈动脉Diam差异无统计学意义(P>0.05);②与对照组相比,家族史阳性组颈动脉参数IMT、PWV、HC升高,Dist降低(均P<0.05);③家族史阳性组之间两两比较:B组的颈动脉IMT、PWV、HC高于F、M组,Dist低于F、M组(均P<0.05);M组的颈动脉PWV、HC高于F组,Dist低于F组(均P<0.05),而组间IMT差异无统计学意义(P>0.05)。结论家族史阳性组的颈动脉僵硬度明显高于对照组,且B组的颈动脉弹性下降最明显,M组次之,F组减低程度最轻。
Objective To evaluate the carotid artery elasticity in the first-degree relatives of patients with type 2 diabetes mellitus.Methods Ninety first-degree relatives of patients with type 2 diabetes who received treatment in the Department of Endocrinology of Henan Provincial People′s Hospital from October 2020 to June 2021 were randomly selected and designated as having a positive family history.Depending on the parental history of diabetes they were divided into three groups:31 cases of family history positive in father(F),31 cases of family history positive in mother(M)and 28 cases of family history positive in both father and mother(B).Thirty cases with matched age,height and weight without any history of diabetes,hypertension,hyperlipidemia and coronary atherosclerotic heart disease in their parents designated as control group were taken for comparison.Real-time intima-media thickness(RIMT)and R-VQS were employed to evaluate common carotid intima-media thickness(IMT),distance(Dist),diameter(Diam),hardness coefficient(HC)and pulse wave velocity(PWV).The differences among the groups were compared.Results①There was no statistical significance in Diam among the four groups(P>0.05).②Compared with the control group,the IMT,PWV and HC in subjects with positive family history were increased,while Dist was decreased(P<0.05).③Paired comparison of the subjects with positive family history:the IMT,PWV and HC in B group were higher than in F and M group,and Dist was lower than in F and M group(P<0.05).The PWV and HC in M group were higher than in F group,and Dist was lower than in F group(P<0.05).There was no statistical significance in IMT between the F and M groups(P>0.05).Conclusions Carotid artery stiffness in the cases with positive family history is significantly higher than the control group.The decrease of carotid elasticity in B group is the most serious,M group takes the second place,while the F group is the least.
作者
郭艳艳
袁建军
吴铭
徐雪艳
马一鸣
张岩岩
张涵
张喜君
朱好辉
Guo Yanyan;Yuan Jianjun;Wu Ming;Xu Xueyan;Ma Yiming;Zhang Yanyan;Zhang Han;Zhang Xijun;Zhu Haohui(Department of Ultrasound,Henan University People′s Hospital,Henan Provincial People′s Hospital,Zhengzhou 450003,China)
出处
《中华超声影像学杂志》
CSCD
北大核心
2021年第12期1039-1045,共7页
Chinese Journal of Ultrasonography
基金
河南省卫健委省部共建项目(SB201901093)
河南省医学科技攻关计划(LHGJ20200057)。
关键词
超声检查
全息血管硬度分析技术
2型糖尿病
一级亲属
颈动脉弹性
Ultrasonography
RF-data based quantitative analysis on vessel stiffness
Type 2 diabetes mellitus
First-degree relatives
Carotid artery elasticity
