摘要
Liver cancer is one of the most common cancers in the world. Of all types of livercancer, hepatocellular carcinoma (HCC) is known to be the most frequent primaryliver malignancy and has seriously compromised the health status of the generalpopulation. Locoregional thermal ablation techniques such as radiofrequency andmicrowave ablation, have attracted attention in clinical practice as an alternativestrategy for HCC treatment. However, their aggressive thermal effect may causeundesirable complications such as hepatic decompensation, hemorrhage, bile ductinjury, extrahepatic organ injuries, and skin burn. In recent years, photodynamictherapy (PDT), a gentle locoregional treatment, has attracted attention in ablationtherapy for patients with superficial or luminal tumors as an alternative treatmentstrategy. However, some inherent defects and extrinsic factors of PDT havelimited its use in clinical practice for deep-seated HCC. In this contribution, theaim is to summarize the current status and challenges of PDT in HCC treatmentand provide potential strategies to overcome these deficiencies in further clinicaltranslational practice.
基金
the Wuhan Municipal Health Commission,No.WX14B22
the National Natural Science Foundation of China,No.81874208 and No.81700425.
