摘要
目的系统评价光动力疗法（PDT）联合胆管支架与单独运用胆管支架引流治疗不可切除胆管癌的疗效。方法计算机检索PubMed、CBM、CNKI、VIP、万方数据库。检索时限为1990年1月1日—2017年12月31日。采用RevMan5．3．0软件进行meta分析。结果共纳入11项研究、659例患者。分析表明PDT与单纯胆管支架引流相比显著延长了患者的生存期限，两者差异有统计学意义（P〈0．01）。PDT与单纯支架引流两组胆管炎发生率差异无统计学意义（P〉0．05）。但PDT组总体并发症发生率较高，两组差异有统计学意义（P〈0．05）。结论Meta分析表明，PDT显著提高了患者的生存期限，且没有带来更高的胆管炎发生率。
Objective To compare the therapeutic results of photodynamic therapy （PDT） combined with biliary stenting versus biliary stenting alone in the treatment of nonresectable bile duct cholangiocarcinoma. Methods The PubMed, CBM, CNKI, VIP and WanFang Data were searched from January 1990 to December 2017. Two researchers independently screened the literatures, extracted the data and performed the quality evaluation. The meta-analysis was carried out using the RevMan software 5.3.0. Results Eleven controlled clinical trials were included in the meta-analysis. There were only two randomized controlled trials. The remaining studies were non-randomized controlled trials. Finally, 659 patients were enrolled in this study. 293 patients were treated with photodynamic therapy and biliary stenting while 366 patients were treated with stenting alone. Analysis showed that photodynamic therapy combined with stenting significantly extended the overall survival when compared with stenting alone （ P〈0.01 ）. There was no significant differences in the incidences of cholangitis （P〉0.05） , but PDT and stenting had a significantly higher total complication rate （P〈0.05）. Conclusions This meta-analysis showed that photodynamic therapy combined with stenting significantly improved the survival rate of patients with nonresectable ductal cholangiocarcinoma when compared with stenting alone. Photodynamic therapy did not increase the incidence of cholangitis.
作者
陈士明
娄玥
方煊
许根兔
陈建尧
Chen Shiming;Lou Yue;Fang Xuan;Xu Gentu;Chen Jianyao(Department of Hepatobiliary-Pancreatic Surgery,Shaoxing Second Hospital,Shaoxing 312000,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2018年第9期616-621,共6页
Chinese Journal of Hepatobiliary Surgery
关键词
胆管癌
不可切除
光动力疗法
胆管支架引流术
META分析
Photodynamic therapy
Cholangiocareinoma
unresectable
Biliary stenting drainage
Meta-analysis
