摘要
目的观察疏肝和中汤治疗肝郁脾虚证腹泻型肠易激综合征(IBS-D)的临床疗效。方法选取南京市中医院2020年3月—2021年3月符合肝郁脾虚证IBS-D诊断标准的患者64例为研究对象,随机分为治疗组(疏肝和中汤)和对照组(枯草杆菌二联活菌肠溶胶囊),每组32例。治疗4周后,评估2组患者的临床症状积分及疗效。结果治疗后,2组主要症状积分、次要症状积分及症状总积分均较治疗前降低,且治疗组主要症状积分、症状总积分均低于对照组,差异有统计学意义(P<0.05)。治疗后,2组各个单项症状积分均降低,且治疗组腹痛、大便性状、急躁易怒、胸闷喜叹息、腹胀单项症状积分低于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组治疗总有效率为93.75%,高于对照组的68.75%,差异有统计学意义(P<0.05)。结论疏肝和中汤能有效缓解肝郁脾虚证IBS-D患者胃肠道症状,提高治疗效果,改善患者生活质量。
Objective To observe the clinical effect of Shugan Hezhong Decoction in the treatment of patients with diarrhea-predominant irritable bowel syndrome(IBS-D) differentiated as liver depression and spleen deficiency syndrome. Methods Totally 64 patients who met the diagnostic criteria of IBS-D differentiated as liver depression and spleen deficiency syndrome in Nanjing City Hospital of Traditional Chinese Medicine from March 2020 to March 2021 were selected and randomly divided into treatment group(treated with Shugan Hezhong Decoction) and control group(treated with live combined bacillus subtilis and enterococcus faecium enteric-coated capsules), with 32 cases in each group. After 4 weeks of treatment, the clinical symptom score and curative effect were evaluated in both groups. Results After treatment, the main symptom score, secondary symptom score and total symptom score in both groups were significantly lower than those before treatment, and the main symptom score and total symptom score of the treatment group were significantly lower than those of the control group(P<0.05). After treatment, the single symptom scores in both groups reduced significantly, and the single symptom scores of abdominal pain, stool shapes and properties, irritability, chest tightness and sigh and abdominal distension in the treatment group were significantly lower than those in the control group(P<0.05). After treatment, the total effective rate in the treatment group was 93.75%, which was significantly higher than 68.75% in the control group(P<0.05). Conclusion Shugan Hezhong Decoction can effectively alleviate the gastrointestinal symptoms of patients with IBS-D differentiated as liver depression and spleen deficiency syndrome,enhance the treatment effect and improve the qualities of life of patients.
作者
王克俭
杨勤
WANG Kejian;YANG Qin(Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu,210001)
出处
《实用临床医药杂志》
CAS
2021年第23期58-61,68,共5页
Journal of Clinical Medicine in Practice
基金
江苏省中医药局科技项目(YX1220)。
关键词
肠易激综合征
肝郁脾虚证
疏肝和中汤
中医药
疗效
irritable bowel syndrome
liver depression and spleen deficiency syndrome
Shugan Hezhong Decoction
traditional Chinese medicine
effect
