摘要
环状RNA(circular RNA,circRNA)是一类通过非经典方式反向剪接形成的环状非编码RNA,在生物体内表达丰富,具有高度保守性、组织发育阶段特异性,且较线性RNA更稳定,可发挥基因表观调控、细胞通信、蛋白质翻译等多种生物功能。近来研究表明,在抑郁症模型动物研究中,circRNA能够影响星形胶质细胞、小胶质细胞的激活和功能,与神经元发育、突触生长以及神经生长因子表达水平等有关。在临床研究中,circRNA有助于抑郁症的诊断及疗效评估。本文就circRNA的生物学特征和功能及其在抑郁症研究中的进展进行综述。
Circular RNAs(circRNAs)are a kind of circular non-coding RNAs,formed by non-classical reverse splicing.They are expressed abundantly in organisms,highly conservative,specific in tissues and developmental stages,and more stable than linear RNA.They play a variety of biological functions,such as gene epigenetic regulation,cell communication,protein translation,etc.Recent studies have shown that,in animal models of depression,circRNAs can affect the activation and function of astrocytes and microglia,and are even related to neuronal development,synaptic growth and expression of nerve growth factors.This article reviews the biological characteristics and functions of circRNAs and their research progress in depression.
作者
谭桂凤
肖颂华
张涵
冯文辉
刘中霖
TAN Gui-feng;XIAO Song-hua;ZHANG Han;FENG Wen-hui;LIU Zhong-lin(Department of Neurology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong,China)
出处
《生命科学研究》
CAS
CSCD
2021年第6期509-513,共5页
Life Science Research
基金
广东省自然科学基金项目(2017A030313490,2018A030313427)
广州市科技计划项目(202002030393)。
