摘要
目的为了提高淫羊藿饮片的质量均一性。方法以淫羊藿饮片中朝藿定C、淫羊藿苷含量为指标,采用均化软件对7批饮片进行均化,比较均化前后不同批次指标成分含量的相对标准偏差(RSD)及指纹图谱相似度的变化以验证均化效果。结果各批次饮片朝藿定C、淫羊藿苷含量的RSD经均化后,分别由52.49%、26.07%降低至6.13%、2.63%,指纹图谱相似度均提高至0.960以上。均化前各指标成分含量的RSD及指纹图谱相似度差异较大,均化后明显降低。结论指标成分含量RSD及指纹图谱相似度的变化提示,不同批次饮片通过均化可显著提高质量均一性。本研究从指标成分含量及指纹图谱相似度的角度对均化结果进行评价,达到了良好的均化效果,适合应用于中药制剂工业化生产的投料过程,可为淫羊藿及其他饮片的均化研究提供借鉴和参考。
Objective To improve the quality uniformity of Epimedium Herb Decoction Pieces.Methods The contents of epimedin C and icariine in Epimedium Herb Decoction Pieces were used as indexes.Homogenization software was used to homogenize seven batches of decoction pieces.The changes of relative standard deviation(RSD)and fingerprint similarity of different batches of index component content before and after homogenization were compared to verify the homogenization effect.Results After homogenization,RSD of epimedin C and icariine content in all batches of decoction pieces decreased from 52.49%and 26.07%to 6.13%and 2.63%,respectively.The similarity of fingerprints was above 0.960.Before homogenization,RSD and fingerprint similarity of each index component content were significantly different,but decreased significantly after homogenization.Conclusion The changes of RSD of index component content and similarity degree of fingerprint indicate that homogenization of different batches of decoction pieces can significantly improve quality uniformity.This study evaluate the homogenization results from the perspective of index component content and fingerprint similarity,and achieve good homogenization effect,which can be applied to the feeding process of industrial production of Traditional Chinese medicine preparations,and can provide reference for the homogenization study of epimedium herb and other decoction pieces.
作者
薛原
吴梅
王优杰
冯怡
刘敏臣
张继全
XUE Yuan;WU Mei;WNAG Youjie;FENG Yi;LIU Minchen;ZHANG Jiquan(Engineering Research Center of the Ministry of Education for Modern Preparation of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai201203,China)
出处
《中国医药导报》
CAS
2021年第35期19-22,共4页
China Medical Herald
基金
上海市科学技术委员会科技创新行动计划项目(16401902300)。
关键词
淫羊藿
均化
高效液相色谱法
指纹图谱
Epimedium herb
Homogenization
High performance liquid chromatography
Fingerprint
