摘要
目的探讨血清N末端B型脑钠肽前体(N-terminal pro-brain natriureticpeptide, NT-proBNP)、高敏肌钙蛋白T(High sensitivity cardiac troponin T,hs-TNT)、血浆脂蛋白相关磷脂酶A2(Plasma lipoprotein related phospholipase A2,Lp-pLA2)水平与急性脑梗死患者神经功能缺损严重程度及预后的相关性,进而评价其联合检测对急性脑梗死预后判定的临床价值。方法选取本院2019年2月-2021年2月的150例急性脑梗死患者作为研究对象,按照NIHSS评分分为3组,分别为轻型组38例、中型组68例及重型组44例,同时随机选取本院同期体检健康人群60例作为对照组;检测并记录所有纳入研究者入院时、患者发病后第24 h, 3 d的NT-proBNP,hs-TNT,Lp-pLA2水平动态变化;根据纳入患者不同预后情况将其分为预后良好组和预后不良组,比较血清NT-proBNP,hs-TNT,Lp-pLA2水平在不同预后组中表达水平的差异,并评价相关预测效能。结果各患者组入院后检测时段内血清NT-proBNP,hs-TNT,Lp-pLA2水平均明显高于对照组(P<0.05),发病后第3 d患者血清NT-proBNP,hs-TNT,Lp-pLA2水平较第24 h均明显下降(P<0.05),其中轻型组、中型组及重型组检测时段内组间血清NT-proBNP,hs-TNT,Lp-pLA2水平亦存在显著差异(P<0.05);150例急性脑梗死患者预后良好102例,预后不良48例,预后不良组血清NT-proBNP,hs-TNT,Lp-pLA2水平均显著高于预后良好组(P<0.05);NT-proBNP,hs-TNT,Lp-pLA2三者联合检测预测预后的效能最高。结论急性脑梗死患者血清NT-proBNP,hs-TNT,Lp-pLA2水平较高,且与NIHSS评分及预后密切相关,可作为临床判断急性脑梗死患者神经功能缺损严重程度和预后的重要血清学生物标志物。
Objective To investigate the correlation between serum levels of NT-proBNP, hs-TNT, Lp-PLA2, neurological function and prognosis in patients with acute cerebral infarction, and to evaluate the clinical value of the combined detection in the prognosis of acute cerebral infarction. Methods A total of 150 patients with acute cerebral infarction in our hospital from Feb. 2019 to Feb. 2021 were selected as the research objects. According to the NIHSS scores, the patients were divided into three groups: mild case group(n=38), moderate case group(n=68) and severe case group(n=44). Meanwhile, 60 healthy people admitted to our hospital in the same period were randomly selected as the control group. The serum NT-proBNP, hs-TNT, Lp-pLA2 levels of all enrolled patients were measured and recorded at admission, 24 hours, 3 days after the onset of disease. According to the different prognosis of the patients, they were divided into the good prognosis group and the poor prognosis group, and the difference between the serum levels of NT-proBNP, hs-TNT, Lp-PLA2 were compared and analyzed, together with related prediction efficiency. Results The serum levels of NT-proBNP, hs-TNT and Lp-pLA2 in patient group were significantly higher than those in the control group during the detection period after admission(P<0.05), and the serum levels of NT-proBNP, hs-TNT and Lp-pLA2 in the third day after the onset of disease were significantly decreased compared with those in 24 h(P<0.05), there were also significant differences in serum levels of NT-proBNP, hs-TNT and Lp-pLA2 among the mild case group, moderate case group and severe case group during the detection period after admission(P<0.05). Of the 150 patients with acute cerebral infarction, 48 cases got poor prognosis and 102 cases got good prognosis. The serum levels of NT-proBNP, hs-TNT and Lp-pLA2 in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05). The combined detection of NT-proBNP, hs-TNT and Lp-pLA2 had the highest prediction effic
作者
徐康
刘启为
陆艳卉
郭佳
韩素桂
Xu Kang;Liu Qiwei;Lu Yanhui(Department of Nuclear Medicine Laboratory,Tangshan People’s Hospital,Tangshan 063001;不详)
出处
《卒中与神经疾病》
2021年第6期631-635,共5页
Stroke and Nervous Diseases
基金
河北省医学科学研究重点课题计划项目(编号为20190172)。
