摘要
目的探讨依达拉奉右莰醇联合阿司匹林辅助治疗缺血性脑卒中的疗效。方法选取2021年6月~2023年3月诊治为缺血性脑卒中的186例患者作为研究对象,采用随机数字表法将其分为两组。两组均进行常规治疗,对照组(93例)给予阿司匹林肠溶片治疗,观察组(93例)给予依达拉奉右莰醇联合阿司匹林治疗,对比两组患者治疗效果、治疗前后神经功能(NIHSS)评分、日常生活能力(ADL)评分、血液流变学水平、血清氧化应激水平[超氧化物歧化酶(SOD)、丙二醛(MDA)]和神经损伤标志物[神经元特异性烯醇化酶(NSE)、特异蛋白100-β(S-100β)]。结果观察组治疗有效率87.10%(81/93)高于对照组70.97%(66/93),差异有统计学意义(P<0.05);两组治疗后NIHSS评分均降低,ADL评分均升高,观察组与对照组相比NIHSS评分较低、ADL评分较高,差异有统计学意义(P<0.05);两组治疗后全血高切黏度、全血低切黏度、血浆黏度水平均降低,观察组水平均较对照组低,差异有统计学意义(P<0.05);两组治疗后MDA水平均降低,且观察组水平均较对照组低,两组SOD水平均升高,且观察组水平较对照组高,差异有统计学意义(P<0.05);两组治疗后NSE、S-100β水平均降低,且观察组水平较对照组低,差异有统计学意义(P<0.05)。结论依达拉奉右莰醇结合阿司匹林治疗能够改善缺血性脑卒中患者的神经功能,减轻脑细胞损伤和氧化应激,提高日常生活能力,调节血液流变学有助于增强治疗效果。
Objective To investigate the efficacy of edaravone dextrocamphorol combined with aspirin in the treatment of ischemic stroke.Methods 186 patients with ischemic stroke from June 2021 to March 2023 were selected as research objects and divided into two groups by random number table method.Both groups received conventional treatment,the control group(93 cases)was given aspirin enteric-coated tablets,the observation group(93 cases)was given edaravone dexcamphorol combined with aspirin.The therapeutic effect,neurological function(NIHSS)score before and after treatment,daily viability(ADL)score,hemorheology level,serum oxidative stress level[superoxide dismutase(SOD),malondialdehyde(MDA)]and and nerve damage markers[Neuron-specific enolase(NSE),specific protein 100-β(S-100β)]were compared between the two groups.Results The effective rate of the observation group was 87.10%(81/93)higher than that of the control group 70.97%(66/93),and a statistically significant differen ce was observed(P<0.05);After treatment,NIFSS score was decreased and ADL score was increased in both groups.Compared with control group,NIFSS score in the observation group was lower and ADL score was higher,and a statistically significant difference was observed(P<0.05);After treatment,the levels of whole blood high tangential viscosity,whole blood low tangential viscosity and plasma viscosity in both groups were decreased,and the levels in the observation group were lower,a statistically significant difference was observed(P<0.05);After treatment,the level of MDA in both groups decreased,and the observation group was lower,and the level of SOD in both groups increased,and the observation group was higher,a statistically significant difference was observed(P<0.05);After treatment,the levels of NSE and S-100βwere decreased in both groups,and the levels in the observation group were lower,a statistically significant difference was observed(P<0.05).Conclusion Edaravone dexcamphorol combined with aspirin can improve the neurological function of patient
作者
吴淑燕
李佩珊
邹巧玲
WU Shu-yan;LI Pei-shan;ZOU Qiao-ling(Department of Pharmacy,Nanhai Hospital,Guangdong Provincial People's Hospital,Foshan 528200,China)
出处
《中国处方药》
2023年第12期142-145,共4页
Journal of China Prescription Drug
基金
佛山市卫生健康局医学科研课题(20210258)。
