摘要
左、右半结直肠癌在流行病学、临床特征、肿瘤分化程度及侵袭性、对治疗的反应、预后、分子学特征等多方面存在显著差异。右半结肠癌发病率低于左半结直肠癌,多见于女性及老年患者,肿瘤分化程度较低,组织浸润及侵袭能力更强,预后差,对表皮生长因子受体靶向治疗不敏感。基于上述差异,目前普遍认为结直肠癌原发灶的解剖部位与预后相关,并且可能是疗效的预测因素。大量研究从基因层面揭示了左、右半结直肠癌的差异,为二者的生物学行为差异提供解释。本文主要综述左、右半结直肠癌差异性研究的进展。
Right-sided colon cancer and left-sided colorectal cancer have significant differences in epidemiology,clinical features,tumor differentiation,response to treatment,prognosis,and molecular characteristics.The former has lower prevalence than the latter and is mainly associated with female and elderly patients,with poor tumor differentiation,strong invasion,poor prognosis,and weak response to epidermal growth factor receptor inhibitors.Thus,it is generally believed that the primary location of colorectal cancer is closely associated with prognosis,acting as an independent prognostic factor for therapeutic efficacy.Recent studies have revealed the genetic differences between right-sided colon cancer and left-sided colorectal cancer,providing explanations for the biological differences.This review summarizes the recent advances on the differences between left-and right-sided colorectal cancer.
作者
钟敏儿
吴斌
ZHONG Min’er;WU Bin(Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2021年第6期980-985,共6页
Acta Academiae Medicinae Sinicae
基金
中国医学科学院医学与健康科技创新工程(2017-I2M-1-009)。
关键词
结直肠癌
右半结肠癌
左半结肠癌
差异性
预后
colorectal cancer
right-sided colon cancer
left-sided colon cancer
difference
prognosis
