摘要
结肠癌作为消化系统最常见的恶性肿瘤之一,大约有1/5的患者在首诊时就存在着远处器官转移,肿瘤发生在左半结肠或右半结肠被认为是判断患者预后的一个重要因素。目前通过对结肠癌临床表现、发病机制的系统研究,发现左半结肠癌(LCC)与右半结肠癌(RCC)存在着明显的差异,这种差异会直接影响对患者治疗方案的选择。因此,本文着重从复发转移机制,分子生物学及治疗预后方面着手,探讨并更好地理解其差异,为结肠癌患者的个体化、精准化治疗提供进一步理论依据。
Colon cancer is one of the most common malignant tumor of digestive system,about 1/5 of colon cancer patients had distant organ metastasis at the first diagnosis,tumor occurrence in the left colon or right colon is considered to be an important factor in judging the prognosis of patients.At present,through systematic research on the clinical manifestations and pathogenesis of colon cancer,the results showed that there was a significant difference between left-sided colon cancer(LCC)and right-sided colon cancer(RCC),which will directly affect the choice of treatment plan for patients.Therefore,in this paper,we mainly study intestinal flora,the mechanism of recurrence and metastasis and prognosis to explore and better understand the differences between left and right colon cancer,providing further theoretical basis for individualized and precise treatment of colon cancer patients.
作者
傅中懋
黄陈
Fu Zhongmao;Huang Chen(Department of Gastrointestinal Surgery,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 201600,China)
出处
《中华结直肠疾病电子杂志》
2019年第6期546-552,共7页
Chinese Journal of Colorectal Diseases(Electronic Edition)
基金
国家自然科学基金面上项目（No.817725276）
上海交通大学医院高峰高原计划（No.20161425）
上海交通大学医工交叉项目（No.YG2017MS28）
上海松江科技攻关项目（No.18sjkjgg23）
关键词
结肠肿瘤
预后
原发部位
差异
临床治疗决策
Colonic neoplasms
Prognosis
Primary site
Difference
Clinical decision-making
