摘要
目的观察增强型体外反搏(EECP)改善血管内皮功能障碍的效果及其对血清内皮细胞特异分子1(endocan-1)、脂肪特异性丝氨酸蛋白酶(vaspin)水平的影响。方法选取2019年11月—2020年6月在本院接受治疗的200例冠心病患者作为研究对象,按随机单盲法分为对照组(n=98)和观察组(n=102)。对照组患者给予常规药物治疗,观察组患者联合给予EECP治疗,比较两组患者的治疗效果及治疗前后血管内皮功能指标和血清endocan-1、vaspin水平的变化。结果观察组患者治疗后心绞痛缓解、运动耐量增加、心绞痛与运动耐量均改善患者的比例分别为82.35%、75.49%和65.69%,明显高于对照组的45.92%、35.71%和24.49%(P<0.05);治疗3周后,两组患者的心绞痛发作频率、持续时间和心肌缺血总负荷均明显减少,且观察组均明显低于对照组(P<0.05)。观察组治疗后肱动脉血流介导的内皮依赖性血管舒张功能(FMD)和硝酸甘油介导的非内皮依赖性血管舒张功能(NMD)较治疗前明显增加,且观察组增加幅度明显高于对照组(P<0.05)。观察组治疗后血清endocan-1比治疗前明显降低,血清vaspin则明显升高,且观察组治疗前后血清endocan-1、vaspin的变化幅度要明显高于对照组(P<0.05)。结论EECP对冠心病的治疗有显著的疗效,其能显著提高心绞痛缓解率,改善血管内皮功能及血清endocan-1、vaspin水平,血清endocan-1、vaspin水平的变化可能是其发挥血管内皮功能保护作用的机制之一。
Aim To observe the effect of enhanced external counter pulsation(EECP)on endothelial dysfunction and the serum levels of endothelial cell specific molecule-1(endocan-1)and fat specific serine protease(vaspin)in patients with coronary heart disease(CHD).Methods 200 patients with coronary heart disease who were treated in our hospital from November 2019 to June 2020 were selected as the research objects and randomly divided into control group(n=98)and observation group(n=102).The patients in the control group were given conventional drug treatment,and the patients in the observation group were added with EECP for 3 weeks.The therapeutic effect and the changes of vascular endothelial function indexes,serum endocan-1 and vaspin levels before and after treatment were compared between the two groups.Results The proportion of patients with angina relief,increased exercise tolerance,angina pectoris and exercise tolerance in the observation group were 82.35%,75.49%and 65.69%,respectively,which were significantly higher than 45.92%,35.71%and 24.49%in the control group(P<0.05).After 3 weeks of treatment,the angina pectoris attack frequency,duration and total myocardial ischemia load in the observation group were significantly lower than those in the control group(P<0.05).Flow-mediated dilation(FMD)and nitroglycerin-mediated dilation(NMD)in the observation group were significantly increased after treatment,and the increase range in the observation group was significantly higher than those in the control group(P<0.05).After treatment,serum endocan-1 in the observation group was significantly lower than that before treatment,while serum vaspin was significantly higher,and the changes of serum endocan-1 and vaspin in the observation group were significantly higher than those in the control group before and after treatment(P<0.05).Conclusions EECP in the treatment of coronary heart disease has a significant effect,it can significantly improve the remission rate of coronary heart disease,improve vascular endothelial function and
作者
张辉
赵东升
王云豹
ZHANG Hui;ZHAO Dongsheng;WANG Yunbao(Department of Ceneral Practice,Hengshui Second People’s Hospital,Hengshui,Hebei 053000,China;Department of Cardiology,Hengshui Second People’s Hospital,Hengshui,Hebei 053000,China;Department of Emergency,Hengshui Second People’s Hospital,Hengshui,Hebei 053000,China)
出处
《中国动脉硬化杂志》
CAS
2022年第2期141-146,共6页
Chinese Journal of Arteriosclerosis
基金
衡水市重点研发计划项目(2019014092Z)。
