摘要
目的: 探讨角膜塑形镜对角膜前表面平坦曲率(Kf<41.00 D)相对平缓患者的近视控制效果及安全性。方法: 前瞻性病例对照研究。收集2018年1月至2019年9月于唐山市眼科医院配镜中心就诊并验配角膜塑形镜的患者80例(120眼)纳入研究组, 验配框架眼镜患者76例(120眼)纳入对照组, 按照等效球镜度(SE)将2组又分别分成低度数组(-3.00-0 D)和中度数组(-6.00--3.25 D)。对各组近视增长幅度、眼轴增长幅度、内皮细胞数量、角膜厚度以及角膜点染等情况进行分析。数据采用独立样本t检验和配对样本t检验进行分析。结果: 戴镜6个月、1年和1.5年, 与对照组相比, 研究组的近视度数增长幅度(低度数组6个月:t=2.314, P=0.023;1年:t=3.215, P=0.002;1.5年:t=4.159, P<0.001。中度数组6个月:t=3.204, P=0.002;1年:t=4.613, P<0.001;1.5年:t=5.160, P<0.001)和眼轴增长幅度(低度数组6个月:t=-2.103, P=0.038;1年:t=-2.129, P=0.037;1.5年:t=-2.398, P=0.020。中度数组6个月:t=-2.094, P=0.039;1年:t=-2.402, P=0.019;1.5年:t=-2.464, P=0.018)均较小。配戴角膜塑形镜后1.5年, 角膜内皮细胞密度、平均细胞面积、变异系数、六角形细胞比率、角膜厚度与戴镜前相比差异均无统计学意义。在配戴角膜塑形镜期间, 眼部均未出现严重并发症。结论: 对于角膜曲率相对平缓的患者, 与框架眼镜比较, 角膜塑形镜在控制眼轴增长和近视度数方面效果较好, 是一种安全有效的近视控制手段。
Objective:To investigate the efficacy and safety of orthokeratology for the control of myopia in patients with flat keratometry(Kf<41.00 D).Methods:This was a prospective controlled study.A total of 80 patients(120 eyes)with orthokeratology lenses were enrolled in the study group and 76 patients(120 eyes)with glasses were enrolled in the control group.The two groups were divided into low(-3.00-0 D)and medium(-6.00--3.25 D)arrays based on spherical equivalent(SE).The myopia increment,axial increment,endothelial cell number,corneal thickness and corneal dot were analyzed in each group.In the data,an independent samples t-test was used for the increase in myopia and axial length,and a paired samples t-test was used for the number of endothelial cells and corneal thickness.Results:Myopia increased when wearing either orthokeratology lenses or glasses for 6 months,1 year and 1.5 years(low degree array:6 months:t=2.314,P=0.023;1 year:t=3.215,P=0.002;1.5 years:t=4.159,P<0.001;medium array:6 months:t=3.204,P=0.002;1 year:t=4.613,P<0.001;1.5 years:t=5.160,P<0.001)and axial growth(low degree array:6 months:t=-2.103,P=0.038;1 year:t=-2.129,P=0.037;1.5 years:t=-2.398,P=0.020;medium array:6 months:t=-2.094,P=0.039;1 year:t=-2.402,P=0.019;1.5 years:t=-2.464,P=0.018).The orthokeratology lens group had significantly lower values than the frame glasses group.1.5 years after wearing orthokeratology lenses,corneal endothelial cell density,average cellular area,coefficient of variation,percentage of hexagonal cells,and corneal thickness had no significant changes compared to values before wearing the lenses.No serious ocular complications occurred while wearing orthokeratology lenses.Conclusions:Orthokeratology lenses can control the growth of the ocular axis significantly and myopia increases more slowly compared with glasses in patients with relatively flat corneal curvature.
作者
韩倩
吕佳
王焕荣
Han Qian;Lyu Jia;Wang Huanrong(Optometry Center of Tangshan Eye Hospital,Tangshan 063000,China)
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2021年第11期835-839,共5页
Chinese Journal Of Optometry Ophthalmology And Visual Science
关键词
角膜塑形术
曲率
近视
眼轴长度
orthokeratology
curvature
myopia
axial length
