摘要
以D-半乳糖致衰老模型小鼠为研究对象,研究了富锗金针菇菌丝体对不同组别实验小鼠血清、肝脏、心脏和脑组织中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)及丙二醛(MDA)含量的影响.实验结果表明:富锗金针菇菌丝体可显著提高衰老模型小鼠肝脏、脑、心脏和血清中的GSH-Px、SOD和T-AOC活性(P<0.01),并显著降低MDA含量(P<0.01).不同剂量的富锗金针菇菌丝体对GSH-Px、SOD、T-AOC活性和MDA含量的作用效果不同,并有剂量效应关系.富锗金针菇菌丝体可以防止自由基对小鼠肝脏、脑、心脏产生的衰老.
The effects of germane-rich Flammulina velutipes mycelium on the contents of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),total antioxidant capacity(T-AOC)and malondialdehyde(MDA)in serum,liver,heart and brain of different groups of mice were studied in aging model mice induced by D-galactose.The experimental results showed that germanic-rich F.veluina mycelium could significantly increase the activities of GSH-Px,SOD and T-AOC in liver,brain,heart and serum of aging model mice(P<0.01),and significantly reduce the content of MDA(P<0.01).Different doses of germanium rich F.velutipes mycelium have different effects on increasing the activities of GSH-Px,SOD,T-AOC and reducing the content of MDA in liver,heart,brain and serum of mice with dose-effect relationship.Germanium rich Flammulina velutipes mycelium can prevent the aging effect of free radicals on the liver,brain and heart of the mice.This study provides a theoretical basis for further research and development of germanic-rich F.velutipes products with anti-aging ability.
作者
朱蕴兰
李亚楠
陈学红
陈宏伟
ZHU Yunlan;LI Yanan;CHEN Xuehong;CHEN Hongwei(Jiangsu Provincial Research Centerof Food Bioprocessing Engineering Technology,College of Food and Bioengineering,Xuzhou Institute of Technology,Xuzhou 221018,China;Jiangsu Provincial Key Construction Laboratory of Food Resource Development and Quality Safety,College of Food and Bioengineering,Xuzhou Institute of Technology,Xuzhou 221018,China)
出处
《徐州工程学院学报（自然科学版）》
CAS
2021年第4期53-58,共6页
Journal of Xuzhou Institute of Technology(Natural Sciences Edition)
基金
江苏省高等学校自然科学研究重大项目(19KJA480002)。
关键词
金针菇
锗
D-半乳糖
衰老模型
抗衰老
Flammulina velutipes
germanium
D-galactose
aging model
anti-aging
