摘要
目的观察帕金森病(PD)伴疲劳(PD-F)患者局部一致性(ReHo)及功能连接(FC),探索其局部脑区分离功能和连接功能。方法纳入29例PD-F患者(PD-F组)和29例PD不伴疲劳(PD-NF)患者(PD-NF组),以35名健康对照者为对照(HC组);采集静息态功能MRI(fMRI),完成临床量表评估;计算ReHo,并分析其与疲劳严重程度量表(FSS)评分的相关性;将2组患者ReHo值存在差异且与FSS相关脑区设为ROI,观察全脑体素水平FC。结果PD-F组右侧罗兰迪克岛盖ReHo值显著降低(体素P=0.001,总体错误率校正P<0.05);PD组右侧罗兰迪克岛盖ReHo值与FSS评分呈负相关(r=-0.539,P<0.001)。PD-F组右侧罗兰迪克岛盖与双侧中扣带回的FC减弱(体素P=0.001,FWE校正P<0.05)。结论PD-F患者右侧罗兰迪克岛盖脑区分离功能且与双侧中扣带回FC异常,并均参与PD-F病理生理机制。
Objective To observe regional homogeneity(ReHo)and functional connectivity(FC)in patients of Parkinson disease(PD)with fatigue(PD-F),and to explore the separation function and connectivity function of PD-F local brain regions.Methods Totally 29 PD-F patients(PD-F group),29 PD without fatigue(PD-NF)patients(PD-NF group)and 35 age and gender matched healthy controls(HC group)were enrolled.All subjects underwent clinical scale evaluation and resting-state functional MRI(fMRI).ReHo was calculated and correlated with the fatigue severity scale(FSS).The brain regions with ReHo differences between PD-F and PD-NF groups and correlated to FSS were set as ROI for FC of the whole brain voxel level.Results ReHo of right Rolandic operculum in PD-F group significantly decreased(voxel P=0.001,family wise error rate correction,P<0.05).ReHo values of right Rolandic operculum in all PD patients were negatively correlated with FSS(r=-0.539,P<0.001).In PD-F group,FC between right Rolandic operculum and bilateral middle cingulate gyrus decreased(voxel P=0.001,FWE correction,P<0.05).Conclusion The dysfunction of right Rolandic operculum local brain region and relative abnormal FC with bilateral middle cingulate gyrus were involved in the pathophysiological mechanism of PD-F.
作者
操纵
余永强
陈先文
王尚培
CAO Zong;YU Yongqiang;CHEN Xianwen;WANG Shangpei(Department of Radiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)
出处
《中国医学影像技术》
CSCD
北大核心
2021年第12期1814-1818,共5页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金面上项目(81771817)。
关键词
帕金森病
疲劳
磁共振成像
局部一致性
功能连接
Parkinson disease
fatigue
magnetic resonance imaging
regional homogeneity
functional connectivity
