摘要
The research of modern pharmacology displays that main material basis of Danggui Shaoyao Powder exerting efficacy includes ligustilide,paeoniflorin,poria acid,ferulic acid,ligustrazine and so on,and its efficacy is mainly realized by regulating neural receptor-ligand interaction,cytokine release,and TNF-αinflammatory pathway.Systematic study of metabonomics,serum pharmacochemistry and network pharmacology of Danggui Shaoyao Powder sufficiently clarifies its potential pharmacodynamic mechanism,and it could provide scientific theoretical basis for its clinical application.In this paper,by systemically analyzing material basis of Danggui Shaoyao Powder,and exploring its complex pharmacological mechanism and clinical application in vivo,it could comprehensively understand the clinical value of Danggui Shaoyao Powder,so as to provide beneficial reference for further development of the material basis,quality control and classical prescription of Danggui Shaoyao Powder.
基金
Youth Project of Hebei Provincial Department of Education(QN2021008)
Projects of the Central Government Guiding Local Scientific and Technological Development(202160201010405)
Start up Fund for Scientific Research of High-level Talents of Chengde Medical University(202103,202106)
Key Discipline Construction Project of Colleges and Universities in Hebei Province(JIJIAOGAO[2013]4)
Technical Innovation Guidance Special Project of Hebei Science and Technology Department-Science and Technology Work Consultation
Youth PI Science and Technology Innovation Team of Herbal Genome of Chengde Medical University.
