摘要
烧伤创面进行性加深是烧伤早期常见的临床问题和治疗难点之一。目前认为,局部缺血缺氧,持续性炎症反应,感染,失衡的局部微环境,细胞坏死、凋亡和自噬等是烧伤创面进行性加深的主要机制。近年来,基础和临床研究提出多种防治烧伤创面进行性加深的新策略和新方法,主要包括:正确冷疗、改善创面血流灌注、早期清创、改善创面微环境、防治创面感染、减轻创面炎症反应、抑制创面氧化应激等。本文着重对烧伤创面进行性加深的防治策略进行综述,以期为烧伤创面治疗提供参考。
The progressive deepening of burn wounds is one of the common clinical problems and difficulties in early burn treatment.At the present,it is believed that local ischemia and hypoxia,persistent inflammation,infection,unbalanced local microenvironment,cell necrosis,apoptosis,and autophagy are the main mechanisms of progressive deepening of burn wounds.In recent years,basic and clinical studies have proposed various new strategies for prevention and treatment of progressive deepening of burn wounds,mainly including correct cooling,improving blood perfusion of the wound,early debridement,improving the wound microenvironment,preventing and treating wound infection,reducing wound inflammation,and inhibiting the oxidative stress in the wound.This review focuses on the current progress of prevention and treatment strategies of burn wound progressive deepening,in order to provide references for the treatment of burn wounds.
作者
李海胜
罗高兴
袁志强
Li Haisheng;Luo Gaoxing;Yuan Zhiqiang(State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Burn Research,the First Affiliated Hospital of Army Medical University(the Third Military Medical University),Chongqing 400038,China)
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2021年第12期1199-1204,共6页
Chinese Journal of Burns
基金
军队医学科技青年培育计划(20QNPY011)
陆军军医大学第一附属医院军事医学与战创伤救治临床新技术计划项目(SWH2016YSCXYB-10)。
关键词
烧伤
创面进行性加深
防治
Burns
Wound progressive deepening
Treatment and prevention
