摘要
外泌体是多种组织细胞分泌的脂质双分子层结构小囊泡,其内含有蛋白质、脂质、mRNA等生物活性成分,具有介导细胞间的物质传递以及信息交流等作用,从而调节细胞的生物学功能。多种不同来源间充质干细胞(MSC)外泌体可通过调节皮肤创面愈合过程中的炎症反应、细胞增殖和迁移、血管生成、胶原沉积等多个阶段,促进伤口愈合并抑制瘢痕形成,在皮肤损伤修复中具有良好的应用前景。本文就不同来源MSC外泌体在皮肤损伤修复中的研究进展作一综述。
Exosomes are lipid bilayer vesicles secreted by a variety of tissues and cells,which contain proteins,lipids,mRNAs and other biological active components.Exosomes have the role of mediating the transfer of substances between cells and the exchange of information to regulate the biologically functions of cells.Studies have shown that exosomes derived from different mesenchymal stem cells can promote wound healing and inhibit scar formation by regulating multiple stages of the inflammatory response,cell proliferation and migration,angiogenesis,collagen deposition and other stages in skin wound healing.In this paper,the research progress of exosomes derived from different mesenchymal stem cells in skin wound is reviewed.
作者
李曼
朱威
张海萍
Li Man;Zhu Wei;Zhang Haiping(Department of Dermatology and Sexually Transmitted Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China)
出处
《中华损伤与修复杂志（电子版）》
CAS
2021年第6期515-519,共5页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
关键词
外泌体
间质干细胞
创伤和损伤
伤口愈合
Exosomes
Mesenchymal stem cells
Wounds and injuries
Wound healing
