摘要
目的研究加减定喘汤联合综合干预对支气管哮喘急性发作期患者肺功能及血清炎性因子水平的影响。方法此次的420例急性发作期支气管哮喘患者作为研究对象选取时间为2019年5月-2020年5月,将其分为对照组(210例)和试验组(210例),分组依据随机数字表法。对照组接受丙酸倍氯米松鼻气雾剂吸入与氨茶碱口服治疗,试验组在对照组基础上联合加减定喘汤治疗,2组患者均连续治疗3个月,并于治疗期间接受综合干预。比较2组患者治疗后中医证候疗效,治疗前后肺功能及血清IL-4、Ig E、IFN-γ水平。结果治疗后,试验组和对照组患者总有效率分别为88.57%和71.43%,试验组显著高于对照组;治疗后2组患者FEV_(1)、FEV_(1)/FVC、PEFR及血清IFN-γ水平与治疗前相比,均显著升高,且试验组与对照组比较,均处于较高水平;治疗后2组患者2组血清IL-4、Ig E水平相比,试验组较低(均P<0.05)。结论定喘汤联合综合干预可有效减轻支气管哮喘急性发作期患者呼吸困难等症状,同时可调节炎性因子水平,对气道炎症反应起到显著抑制作用,且可改善其肺功能,治疗效果显著。
Objective To study the effect of modified Dingchuan decoction combined with comprehensive intervention on pulmonary function and serum inflammatory factors in patients with acute exacerbation bronchial asthma.Methods 420 cases of bronchial asthma patients in our hospital were selected from May 2019 to may 2020.They were divided into control group(n=210)and experimental group(n=210).The grouping was based on random number table.The control group was treated with beclomethasone propionate nasal aerosol inhalation and oral aminophylline,while the experimental group was treated with modified Dingchuan decoction on the basis of the control group.Both groups were treated for 3 months continuously,and received comprehensive intervention during the treatment.The curative effect of traditional Chinese medicine syndrome,lung function and serum IL-4,Ig E,IFN-γlevels before and after treatment were compared between the two groups.Results After treatment,the total effective rates of the experimental group and the control group were 88.57%and71.43%respectively,and the total effective rate of the experimental group was significantly higher than the control group.After treatment,the levels of FEV_(1),FEV_(1)/FVC,PEFR and serum IFN-γin the two groups were significantly higher than those before treatment,and the experimental group was at a higher level than the control group.After treatment,the levels of serum IL-4 and Ig E in the experimental group were significantly higher than those in the control group(all P<0.05).Conclusion Modified Dingchuan decoction combined with comprehensive intervention can effectively alleviate the symptoms of dyspnea in patients with acute exacerbation bronchial asthma,at the same time,it can adjust the level of inflammatory factors,significantly inhibit the airway inflammatory reaction,and can improve the pulmonary function.
作者
崔青云
CUI Qingyun(Department of Internal Medicine,People's Hospital of Xiangfen Medical Group,Shanxi Province,Xiangfen 041500,China)
出处
《光明中医》
2021年第21期3570-3573,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
哮证
支气管哮喘
急性发作期
定喘汤
综合干预
asthma
bronchial asthma
acute exacerbation
Dingchuan decoction
comprehensive intervention
pulmonary function
inflammatory factors
