摘要
目的分析雾化吸入布地奈德气雾剂、静脉注射甲泼尼龙琥珀酸钠治疗哮喘急性发作患者的效果。方法选取2018年7月至2019年7月我院收治的94例哮喘急性发作患者作为研究对象,采用随机数字法将其分为治疗①组和治疗②组,各47例。治疗①组接受静脉注射甲泼尼龙琥珀酸钠治疗,治疗②组接受雾化吸入布地奈德气雾剂治疗。比较两组治疗前、治疗1周后的免疫功能指标、炎症因子指标、肺功能指标及哮喘生活质量问卷(AQLQ)评分。结果治疗1周后,治疗②组的CD4^(+)、CD3^(+)、IL-10水平、PEFR、FVC、FEV_(1)、AQLQ评分高于治疗①组,IL-5水平低于治疗①组(P<0.05)。结论相较于静脉注射甲泼尼龙琥珀酸钠,雾化吸入布地奈德气雾剂治疗哮喘急性发作患者的效果更佳,可明显改善免疫功能指标、炎症因子指标,有利于肺功能恢复,促进症状消退,提升生活质量。
Objective To analyze the effects of nebulized budesonide aerosol inhalation and intravenous methylprednisolone sodium succinate in the treatment of patients with acute attack of asthma.Methods A total of 94 patients with acute attack of asthma treated in our hospital from July 2018 to July 2019 were selected as the research objects.The patients were divided into treatment①group and treatment②group according to random number method,with 47 cases in each group.The treatment①group received intravenous methylprednisolone sodium succinate,and the treatment②group received nebulized budesonide aerosol inhalation.The indexes of immune function,inflammatory factors,lung function and asthma quality of life questionnaire(AQLQ)score before and after 1 week of treatment were compared between the two groups.Results After 1 week of treatment,CD4^(+),CD3^(+),IL-10 level,PEFR,FVC,FEV_(1) and AQLQ score in the treatment②group were higher than those in the treatment①group,and IL-5 level was lower than that in the treatment①group(P<0.05).Conclusion Compared with intravenous methylprednisolone sodium succinate,nebulized budesonide aerosol inhalation has better effect in the treatment of patients with acute attack of asthma,it can significantly improve the indexes of immune function and inflammatory factors,which is conducive to the recovery of lung function,promote the regression of symptoms and improve the quality of life.
作者
费劲萌
申文琦
FEI Jinmeng;SHEN Wenqi(Shaanxi Provincial Tuberculosis Prevention and Control Hospital,Xi'an 710100;People's Hospital of Lintong District,Xi'an 710600,China)
出处
《临床医学研究与实践》
2021年第35期44-46,共3页
Clinical Research and Practice
关键词
布地奈德
甲泼尼龙琥珀酸钠
哮喘急性发作
炎症因子
肺功能
临床症状
budesonide
methylprednisolone sodium succinate
acute attack of asthma
inflammatory factors
pulmonary function
clinical symptoms
