摘要
目的分析老年冠心病(CHD)患者尿酸、颈动脉内膜中层厚度(IMT)变化与其预后的关系。方法选取2017年9月~2019年9月本院收治的103例CHD患者(研究组),其中稳定性心绞痛(SAP)患者30例、不稳定心绞痛(UAP)患者36例,急性心肌梗死(AMI)37例,分别作为SAP组、UAP组和AMI组;同时纳入105例因疑似冠心病入院检查而结果正常者作为对照组。对比所有受试者中血尿酸、IMT、斑块指数的差异。所有CHD者均进行经皮冠状动脉介入治疗(PCI),多元Logistic回归分析影响CHD患者经PCI治疗后发生心血管事件的危险因素。Pearson分析血尿酸与IMT的相关性。结果研究组血尿酸水平、IMT、斑块指数均高于对照组(均P<0.05)。血尿酸水平、IMT、斑块指数由高到低依次为AMI组、UAP组、SAP组,两两比较均具有统计学意义(P<0.05)。103例CHD患者经PCI治疗后共出现42例心血管事件。BMI、病变支数、血脂、血肌酐、尿酸水平、IMT、斑块指数异常与CHD患者经PCI治疗后发生心血管事件显著相关(P<0.05);血脂、IMT、斑块指数异常为影响CHD患者经PCI治疗后发生心血管事件的多因素(P<0.05);IMT与血尿酸水平呈正相关(P<0.05)。结论老年CHD患者血尿酸水平与IMT正相关,两者均为影响患者PCI治疗后发生心血管事件的独立危险因素,可作为临床评估CHD患者预后的有效指标。
Objective To analyze the relationship between the changes of uric acid,carotid intima-media thickness(IMT)and the prognosis of elderly patients with coronary heart disease(CHD).Methods The 103 CHD patients admitted to our hospital from September 2017 to September 2019 were selected,including 30 patients with stable angina pectoris(SAP)and 36 patients with unstable angina pectoris(UAP),and 37 patients with acute myocardial infraction(AMI),which were classified as SAP group,UAP group and AMI group respectively.At the same time,105 patients with normal results admitted to this hospital suspected coronary heart disease were selected as the control group.The differences in blood uric acid,IMT,and plaque index in all subjects were compared.All patients with CHD underwent percutaneous coronary intervention(PCI).Multivariate Logistic regression analysis was used to analyze the risk factors of cardiovascular events in CHD patients after PCI treatment.Pearson was used to analyze the correlation between blood uric acid and IMT.Results The blood uric acid level of the study group was higher than that of the control group,and the IMT and plaque index were higher than those of the control group(P<0.05).The order of the three groups according to blood uric acid level,IMT and plaque index in descending order were AMI group,UAP group,and SAP group.The pairwise comparison of the three groups was statistically significant(P<0.05).There were 42 patients with cardiovascular events in 103 patients with CHD after PCI treatment.BMI,number of diseased branches,blood lipids,blood creatinine,uric acid level,IMT,plaque index abnormalities were significantly related to the occurrence of cardiovascular events in CHD patients after PCI treatment(P<0.05).Abnormal blood lipids,IMT,and plaque index were multiple factors that affected the occurrence of cardiovascular events in CHD patients after PCI treatment(P<0.05).IMT had positive correlation with blood uric acid level(P<0.05).Conclusion The serum uric acid level of elderly patients with CHD is
作者
刘军
李宏增
高砚丽
任引刚
汪杰
刘慧
LIU Jun;LI Hongzeng;GAO Yanli;REN Yingang;WANG Jie;LIU Hui(The Second Affiliated Hospital of PLA Air Force Medical University, Xi'an 710038, China)
出处
《西部医学》
2021年第12期1793-1796,1806,共5页
Medical Journal of West China
基金
陕西省重点研发计划(2019SF-202)
唐都医院创新发展基金资助项目(2018QYTS011)。
关键词
冠心病
尿酸
颈动脉内膜中层厚度
预后
Coronary heart disease
Uric acid
Carotid artery intima-media thickness
Prognosis
