摘要
目的调查临床的一般资料(年龄、性别)和实验室参数(血清尿酸,血清补体)作为标记IgA肾病(IgAN)患者进展的可靠性。方法总共纳入111例IgAN患者,随访期均>1年或达到终末期肾脏病,通过比较患者研究资料进行统计分析。结果所有患者平均随访期为(33±29)个月,其中37例(33.3%)患者发展到终末期肾脏病,结果表明,血清尿酸和补体C3/C4染色在e GFR>30 m L/(min·1.73 m2)患者中表达差异具有统计学意义(P<0.05)。结论高尿酸血症和补体沉积是IgAN进展的独立危险因素。
Objective To investigate the utility of clinical[age,gender]and laboratory parameters[eGFR,serum levels of uric acid,albumin]and pattern of staining for C3,as progression markers in patients with IgA Nephropathy(IgAN).Methods A total of111IgAN patients with a follow-up period>1year or who reached kidney failure[GFR category G5chronic kidney disease(CKD)]<1year were investigated.Results Mean follow-up period was(33±29)months.Thirty-seven(33.3%)patients progressed to kidney failure.In multivariate analysis,Serum uric acid level was associated independently with T score in patients with eGFR>eGFR>30mL/(min·1.73m2)(P<0.05).Conclusion Hyperuricemia and the deposition of C3are independent risk factors for IgAN progression.
作者
孙娜
SUN Na(Department of Nephrology,Tianjin First Center Hospital. Tianjin 300192, China)
出处
《中国处方药》
2017年第8期105-106,共2页
Journal of China Prescription Drug
