摘要
目的基于Meta分析和网络药理学,综合评价胃复春联合常规化学药治疗消化性溃疡的疗效,并初步探讨其潜在作用机制。方法通过检索中国知网(CNKI)、万方(Wangfang)、维普(VIP)、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library、Web of Science等数据库,收集胃复春联合常规化学药治疗消化性溃疡的随机对照试验,根据纳入和排除标准对所有文献进行筛选,采用Stata16.0软件进行Meta分析;随后检索TCMSP数据库、BATMAN-TCM数据库,筛选胃复春的化学成分及其作用靶点,并与消化性溃疡疾病靶点映射对比后取得潜在作用靶点,利用生物信息学技术进行分析,初步探讨其作用机制。结果Meta分析共纳入文献14篇,1885例患者,结果显示,胃复春联用常规化学药治疗消化性溃疡能够提高幽门螺杆菌根除率以及临床疗效,并降低胃泌素水平。网络药理学共得到64种成分、65个共有靶点与160条相关通路,主要涉及核因子-κB(nuclear factorκB,NF-κB)信号通路、晚期糖基化终产物及其受体(advanced glycation end products-receptor for advanced glycation end products,AGE-RAGE)信号通路、肿瘤坏死因子(tumor necrosis factor,TNF)信号通路等。结论胃复春联用常规化学药治疗消化性溃疡可能是通过减轻幽门螺杆菌感染所导致的炎症反应来达到治疗目的。
Objective To comprehensively evaluate the efficacy of Weifuchun(胃复春)combined with conventional Western medicine in the treatment of peptic ulcer based on Meta-analysis and network pharmacology,and preliminarily explore its potential action mechanism.Methods Weifuchun combined with conventional Western medicine of randomized controlled trials for the treatment of peptic ulcer were collected by searching databases such as CNKI,Wangfang,VIP,CBM,PubMed,Cochrane Library,Web of Science;All literatures were screened based on inclusion and exclusion criteria and Stata16.0 software was used for Meta-analysis.Then the chemical components and the targets of Weifuchun for the treatment of peptic ulcer were screened by searching the TCMSP database and BATMAN-TCM database,and the potential targets were obtained after mapping with the targets of peptic ulcer disease,and bioinformatics techniques are used to analyze and preliminarily explore the action mechanism.Results Meta-analysis included 14 articles and 1885 patients totally.The results showed that Weifuchun combined with conventional Western medicine to treat peptic ulcer could improve the eradication rate of helicobacter pylori(Hp)and the clinical curative effect,and reduce the level of gastrin;Network pharmacology obtained 64 ingredients,65 targets and 160 related pathways,mainly related to nuclear factorκB(NF-κB)signaling pathway,advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway,tumor necrosis factor(TNF)signaling pathway and so on.Conclusion Weifuchun combined with conventional Western medicine in the treatment of peptic ulcer may be achieved by alleviating the inflammatory response caused by Hp infection.
作者
杨恒
杨家越
代耀
赵艳玲
马骁
曾进浩
YANG Heng;YANG Jia-yue;DAI Yao;ZHAO Yan-ling;MA Xiao;ZENG Jin-hao(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of Standardization of Chinese Materia Medica,Ministry of Education,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Department of Pharmacy,Fifth Medical Center of China PLA General Hospital,Beijing 100039,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第21期6625-6636,共12页
Chinese Traditional and Herbal Drugs
基金
国家重点研发计划资助(2018YFC1704500,2018YFC1704504)
国家自然科学基金项目(81804066,81904178)
四川省教育厅自然科学重点项目(18ZA0186)
成都中医药大学教改建设项目(JGZD201918)
成都中医药大学杏林学者学科人才科研提升计划(QNXZ2018025)。
