摘要
目的探讨2型糖尿病患者的体液免疫指标水平与血糖、胰岛素水平的相关性。方法选取2020年6月—2021年6月该院确诊的2型糖尿病患者130例作为观察组,选择在该院进行健康体检人群130名作为对照组,比较两组研究对象的血清免疫球蛋白IgA、IgM、IgG和补体C3、C4、血糖和胰岛素水平及分析体液免疫指标与血糖和胰岛素水平的相关性。结果观察组研究对象的血清免疫球蛋白IgA、IgG、IgM、补体C3、C4水平高于对照组,差异有统计学意义(P<0.05)。两组研究对象的空腹血糖和胰岛素水平比较,差异有统计学意义(P<0.001)。采用Pearson相关性分析结果显示2型糖尿病患者免疫球蛋白IgA、IgG、IgM、补体C3和C4与空腹血糖和胰岛素水平呈正相关。结论 2型糖尿病患者不但可通过监测血清免疫球蛋白IgA、IgM、IgG和补体C3、C4等体液免疫指标做为诊断的辅助指标,也可通过改善机体的体液免疫提高2型糖尿病治疗的预后。
Objective To investigate the correlation between humoral immunity and blood glucose and insulin levels in patients with type 2 diabetes mellitus.Methods A total of 130 patients with type 2 diabetes diagnosed in the hospital from June 2020 to June 2021 were selected as the observation group,and 130 people who underwent a physical examination in the hospital were selected as the control group.The serum immunoglobulins IgA,IgM,IgG and complement C3,C4,blood glucose and insulin levels of the two groups of subjects were compared,and the correlation between humoral immune indicators and blood glucose and insulin levels was analyzed.Results The serum immunoglobulins IgA,IgG,IgM,complement C3,and C4 levels of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05).Compared the fasting blood glucose and insulin levels of the two groups of subjects,the difference was statistically significant(P<0.001).Pearson correlation analysis results showed that immunoglobulins IgA,IgG,IgM,complement C3 and C4 were positively correlated with fasting blood glucose and insulin levels in patients with type 2 diabetes.Conclusion In patients with type 2 diabetes,humoral immune indexes such as IgA,IgM,IgG and complement C3 and C4 can be monitored as auxiliary indexes for diagnosis,and the prognosis of type 2 diabetes treatment can be improved by improving humoral immunity.
作者
杨伟
陈良娟
彭雪峰
YANG Wei;CHEN Liangjuan;PENG Xuefeng(Department of Laboratory Medicine,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou,Fujian Province,362000 China;Department of Pathology,Quanzhou First Hospital,Fujian Medical University,Quanzhou,Fujian Province,362000 China;Department of Endocrinology,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou,Fujian Province,362000 China)
出处
《糖尿病新世界》
2021年第19期58-61,共4页
Diabetes New World Magazine
关键词
2型糖尿病
体液免疫
血糖
胰岛素
相关性
Type 2 diabetes
Humoral immunity
Blood glucose
Insulin
Correlation
