摘要
目的探讨奥美拉唑与多潘立酮治疗儿童功能性消化不良的临床效果。方法随机择取该院于2017年2月—2018年2月间就诊治疗的功能性消化不良患儿共计200例,以乱数表法形式均分为研究组和对照组,每组100例。对照组口服奥美拉唑,研究组行奥美拉唑+多潘立酮。比较两组胃动过缓、胃电节律障碍发生率;临床症状消失情况、外周血水平及治疗疗效。结果治疗后研究组及对照组胃动过缓(4.00%vs 6.00%)、胃电节律障碍发生率(8.00%vs16.00%)比较,差异无统计学意义(P>0.05);治疗后研究组腹部疼痛94.00%、腹部发胀92.00%、饱腹明显98.00%、恶心呕吐90.00%等反应消失占比高于对照组(80.00%、76.00%、82.00%、72.00%),差异有统计学意义(P<0.05);治疗前两组MOT、GAS、NPY以及LEP水平比较,差异无统计学意义(P>0.05),经治疗后研究组MOT、GAS、NPY水平高于对照组,差异有统计学意义(P<0.05),两组LEP水平比较,差异无统计学意义(t=0.794,P=0.428);研究组治疗有效率为94.00%,高于对照组的78.00%,差异有统计学意义(χ^(2)=10.631,P=0.001)。结论奥美拉唑以及多潘立酮均可有效治疗功能性消化不良,而联合用药可显著调节外周血水平,提升治疗效果,显著缓解不良反应。
Objective To explore the clinical effects of omeprazole and domperidone in the treatment of children with functional dyspepsia.Methods Randomly selected 200 children with functional dyspepsia treated in the hospital between February 2017 and February 2018 were selected and divided into the study group and the control group in the form of a random number table,with 100 cases in each group.The control group received omeprazole orally,and the study group received omeprazole+domperidone.The two groups were compared the incidence of bradycardia and electrical gastric rhythm disorder;the disappearance of clinical symptoms,peripheral blood levels and therapeutic effects.Results After treatment,there was no statistically significant difference between the study group and the control group for bradycardia(4.00%vs 6.00%)and the incidence of electrical gastric rhythm disorder(8.00%vs 16.00%)(P>0.05);after treatment,94.00%of abdominal pain,92.00%of swollen abdomen,98.00%of obvious fullness of and 90.00%of nausea and vomiting disappeared of the study group more than the control group(80.00%,76.00%,82.00%,72.00%),the difference was statistically significant(P<0.05);the comparison of MOT,GAS,NPY and LEP levels between the two groups before treatment showed no statistically significant difference between the groups(P>0.05).After treatment,the MOT,GAS,and NPY levels of the study group were higher than those of the control group,the difference was statistically significant(P<0.05),compared with LEP level,the difference between the two groups was not statistically significant(t=0.794,P=0.428);the effective rate of treatment in the study group was 94.00%,which was higher than that of the control group78.00%,the difference was statistically significant(χ^(2)=10.631,P=0.001).Conclusion Both omeprazole and domperidone can effectively treat functional dyspepsia,and the combined medication can significantly adjust the peripheral blood level,improve the therapeutic effect,and significantly alleviate the adverse reactions.
作者
王长安
WANG Changan(Department of Pediatrics,Fuqing Maternal and Child Health Hospital,Fuqing,Fujian Province,350300China)
出处
《中外医疗》
2021年第28期101-104,共4页
China & Foreign Medical Treatment
关键词
奥美拉唑
多潘立酮
功能性消化不良
外周血指标
效果分析
Omeprazole
Domperidone
Functional dyspepsia
Peripheral blood indicators
Effect analysis
