摘要
目的观察甲巯咪唑治疗甲状腺功能亢进症的临床效果。方法选取诸暨市中心医院2016年1月至2019年6月收治的甲状腺功能亢进症患者110例为研究对象。采用随机数字表法分为两组,对照组55例予以丙硫氧嘧啶治疗,观察组55例予以甲巯咪唑治疗,两组疗程6个月。比较两组甲状腺功能指标、骨代谢指标、临床疗效及不良反应发生情况。结果治疗后,观察组游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)分别为(4.46±1.02)pmol/L、(14.45±2.16)pmol/L、(1.89±0.64)mU/L,均低于对照组的(6.37±1.38)pmol/L、(18.54±4.46)pmol/L、(3.47±0.99)mU/L,差异均有统计学意义(t=8.254、6.121、9.940,均P<0.05);观察组降钙素(CT)为(68.62±6.75)ng/L,高于对照组的(61.45±6.47)ng/L,血清骨钙素(BGP)为(6.38±1.64)ng/L,低于对照组的(8.21±2.19)ng/L,差异均有统计学意义(t=5.687、4.960,均P<0.05);观察组总有效率为92.73%(51/55),高于对照组的78.18%(43/55),不良反应发生率为9.09%(5/55),低于对照组的25.45%(14/55),差异均有统计学意义(χ^(2)=4.681、5.153,均P<0.05)。结论甲巯咪唑治疗甲状腺功能亢进症安全有效,可促使甲状腺功能、骨代谢功能得到有效改善,有一定的临床意义和创新性。
Objective To investigate the clinical efficacy of methimazole in the treatment of hyperthyroidism.Methods A total of 110 patients with hyperthyroidism who received treatment in Zhuji Central Hospital between January 2016 and June 2019 were included in this study.They were randomly assigned to receive treatment either with propylthiouracil(control group,n=55)or methimazole(observation group,n=55)for 6 successive months.Thyroid function indicators,bone metabolism indicators,clinical efficacy,and adverse events were compared between the control and observation groups.Results After treatment,free triiodothyronine(FT3),free thyroxine(FT4)and thyroid stimulating hormone(TSH)levels in the observation group were(4.46±1.02)pmol/L,(14.45±2.16)pmol/L and(1.89±0.64)mU/L respectively,which were significantly lower than those in the control group[(6.37±1.38)pmol/L,(18.54±4.46)pmol/L and(3.47±0.99)mU/L,t=8.254,6.121,9.940,all P<0.05).Calcitonin level in the observation group was significantly higher than that in the control group[(68.62±6.75)ng/L vs.(61.45±6.47)ng/L,t=5.687,P<0.05].Bone Gla-protein level in the observation group was significantly lower than that in the control group[(6.38±1.64)ng/L vs.(8.21±2.19)ng/L,t=4.960,P<0.05].Total effective rate in the observation group was significantly higher than that in the control group[92.73%(51/55)vs.78.18%(43/55),χ²=4.681,P<0.05].Adverse reaction rate in the observation group was significantly lower than that in the control group[9.09%(5/55)vs.25.45%(14/55),χ²=5.153,P<0.05].Conclusion Methimazole is safe and effective in the treatment of hyperthyroidism,which can effectively improve thyroid function and bone metabolism.This study is of certain clinical significance and innovation.
作者
应丹丹
李楠
王文光
Ying Dandan;Li Nan;Wang Wenguang(First Department of Internal Medicine,Zhuji Central Hospital,Zhuji 311800,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2021年第12期1771-1774,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省医药卫生科技计划项目(2019ZD059)。
