摘要
目的 探讨比索洛尔联合甲巯咪唑治疗甲状腺功能亢进症（甲亢）的临床疗效.方法 将100例甲亢患者随机分为对照组（甲巯咪唑治疗）50例和治疗组（比索洛尔联合甲巯咪唑治疗）50例,观察临床疗效和患者血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、高敏促甲状腺激素（S-TSH）的变.结果 治疗组总有效率92.0%,明显高于对照组的78.0%（χ2=3.798,P＜0.05）;两组治疗后TT3、TT4、FT3、FT4含量均低于治疗前（t=2.245,t=2.315,t=2.411,t=2.381,均P＜0.05）,S-TSH含量高于治疗前（t=2.335,P＜0.05）;治疗组甲亢指数积分下降较对照组明显（t=2.312,P＜0.05）.结论 比索洛尔联合甲巯咪唑治疗甲亢能有效改善临床症状,提高疗效.
Objective To explore the clinical effect and safety of bisoprolol combined with methimazole in treatment of hyperthyroidism.Methods 100 cases with hyperthyroidism were randomly divided into control group （methimazole treatment）50 case.$and treatment group（bisoprolol combined with methimazole treatment）50 cases.The therapeutic effect,serum levels of FT3,FT4 and s-TSH were observed.Results The total effective rate in treatment group 92.0% was significantly higher than 78.0%in control group（χ2=3.798,P〈0.05）;The contents of TT3,TT4,FT3,FT4 after treatment were lower than before treatment（t=2.245,2.315,2.411,all P〈0.05）;The contents of S-TSH was higher than before treatment（t=2.335,P〈0.05）;Hyperthyroidism exponential integral in treatment group decreased significantly than the control group（t=2.312,P〈0.05）.Conclusion The bisoprolol combined with methimazole treatment could efficiently improve clinical symptoms,raise therapeutic effect in patients with hyperthyroidism.
出处
《中国基层医药》
CAS
2011年第9期1196-1198,共3页
Chinese Journal of Primary Medicine and Pharmacy
