摘要
肾脏疾病是临床常见病、多发病,是指各种原因导致的肾脏结构和功能的破坏,可分为原发性、继发性及遗传性肾脏疾病。临床上,肾脏结构和功能的损害通常是一个慢性进展性过程,其导致的慢性肾脏病已成为全世界危害人类健康的重大公共卫生问题。Notch信号通路可影响细胞的增殖、分化、迁移、生长和凋亡等过程,决定细胞的命运,Notch的异常表达或基因突变会引起组织损伤导致各种肾脏疾病的发生和发展。中医药作为防治肾脏疾病的重要手段,具有多种成分作用于多个靶点和多条信号通路的特点,常被用作慢性肾脏病治疗的常规或潜在的补充疗法和丰富的新药发现来源。近年来,因西医治疗对肾脏疾病的局限性,越来越多的学者开始在中医药防治肾脏疾病领域中以Notch信号通路为切入点,进行对各种单味中药或其提取物、中成药及中药复方调控Notch信号通路的临床和实验性研究,并观测到中医药通过抑制Notch信号通路而发挥肾脏保护作用。文章通过收集中医药防治各种肾脏疾病的相关文献,重点对通过调控Notch信号通路发挥防治糖尿病肾病,免疫球蛋白A(IgA)肾病,肾纤维化,膜性肾病,局灶节段性肾小球硬化,肾细胞癌等慢性肾脏病作用的研究文献进行梳理,分析并总结目前研究现状,以期为临床防治各种肾脏疾病提供参考意见,同时为中医药的普遍运用增加事实依据。
As common and frequently-occurring disorders in clinic practice,renal diseases are characterized by the impairment of kidney structure and function due to a variety of reasons and can be divided into primary,secondary,and hereditary types.Clinically,the impairment of kidney structure and function is usually a chronic progressive process,and the resulting chronic renal diseases have become a major public health problem endangering human health worldwide.Notch signaling pathway affects cell proliferation,differentiation,migration,growth,and apoptosis and determines the fate of cells.Abnormal expression or gene mutation of Notch will cause tissue damage,followed by the occurrence and development of a variety of renal diseases.Traditional Chinese medicine(TCM),as an important means to prevent and treat renal diseases,has the characteristics of acting on multiple targets and signaling pathways with multiple components,and is often used as a routine or potential complementary therapy for the treatment of chronic renal diseases and also a source of new drug discovery.In recent years,considering the limitations of western medicine in treating renal diseases,more and more scholars have begun to take Notch signaling pathway as the breakthrough point for exploring TCM prevention and treatment of renal diseases.They have conducted clinical and experimental studies on the regulation of Notch signaling pathway by a variety of individual Chinese herbs or their extracts,Chinese patent medicines,and Chinese medicinal compounds,and found that TCM exerted the renal protective effects by inhibiting the Notch signaling pathway.By collecting relevant literatures on TCM prevention and treatment of various renal diseases,especially those concerning TCM regulation of Notch signaling pathway for preventing and treating such chronic renal diseases as diabetic nephropathy,immunoglobulin A(IgA)nephropathy,renal fibrosis,membranous nephropathy,focal segmental glomerulosclerosis,and renal cell carcinoma,this paper summarized the current resear
作者
孙倩
李姗姗
杨少宁
于小勇
SUN Qian;LI Shan-shan;YANG Shao-ning;YU Xiao-yong(The First School of Clinical Medicine of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi'an 710003,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第24期227-234,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
陕西省科学技术厅一般项目(2017SF-298)。
