摘要
目的探讨康复新液联合种植义齿治疗慢性牙周炎伴牙列缺损的疗效,以及对患者咀嚼功能的影响。方法选取医院2019年5月至2020年5月收治的慢性牙周炎伴牙列缺损患者114例,按随机数字表法分为观察组和对照组,各57例。两组患者均行种植义齿修复术治疗,观察组加用康复新液含漱。均治疗4周,随访3个月。结果观察组自愿退出2例、未严格执行治疗方案2例,对照组自愿退出2例、病情发生变化更改治疗方案2例、失访1例,均予以剔除。观察组总有效率为90.57%,显著高于对照组的75.00%(Z=4.477,P=0.034)。治疗后,观察组患者的牙周探诊深度、龈沟出血指数、牙齿松动度分别为(1.97±0.53)mm,(1.19±0.44)分,(1.37±0.73)mm,分别低于对照组的(2.31±0.62)mm,(1.57±0.53)分,(1.98±0.76)mm,差异有统计学意义(t=3.022,4.001,4.195,P=0.003,0.000,0.000);观察组患者的乳铁蛋白、前列腺素E_(2)、NF-κB受体激活蛋白配体水平分别为(154.12±15.12)ng/L,(87.10±10.20)ng/L,(58.17±7.17)g/L,分别低于对照组的(172.09±17.02)ng/L,(96.31±11.05)ng/L,(66.92±8.10)g/L,差异有统计学意义(t=5.722,4.439,5.864,P=0.000,0.000,0.000);观察组患者的咀嚼、发音、吞咽功能评分分别为(7.95±1.97)分,(8.18±1.81)分,(8.54±1.57)分,分别高于对照组的(6.82±1.86)分,(7.41±1.66)分,(7.48±1.46)分,差异有统计学意义(t=3.021,2.271,3.581,P=0.003,0.025,0.001)。观察组和对照组不良反应发生率相当(16.98%比11.54%,χ^(2)=0.635,P=0.426)。结论康复新液联合种植义齿治疗慢性牙周炎伴牙列缺损疗效良好,能改善患者的牙周健康状况及咀嚼、吞咽功能,降低血清炎性细胞因子水平,且治疗安全性良好。
Objective To investigate the clinical efficacy of Kangfuxin Liquid combined with implant denture in the treatment of chronic periodontitis with dentition defect and its effect on masticatory function.Methods A total of 114 patients with chronic periodontitis with dentition defect admitted to the hospital from May 2019 to May 2020 were selected and divided into the observation group and the control group by the random number table method,57 cases in each group.The patients in the two groups were treated with implant denture,on this basis,the patients in the observation group were treated with Kangfuxin Liquid.Both groups were treated for four weeks and followed up for three months.Results Two cases voluntarily withdrew and two cases did not strictly implement the treatment plan in the observation group,while two cases voluntarily withdrew,two cases changed the treatment plan and one case lost the follow-up in the control group,and all of them were excludued.The total effective rate of the observation group was 90.57%,which was significantly higher than 75.00%of the control group(Z=4.477,P=0.034).After treatment,the periodontal probing depth,sulcus bleeding index(SBI)and tooth mobility in the observation group were(1.97±0.53)mm,(1.19±0.44)points and(1.37±0.73)mm respectively,which were significantly lower than(2.31±0.62)mm,(1.57±0.53)points and(1.98±0.76)mm in the control group(t=3.022,4.001,4.195,P=0.003,0.000,0.000).The levels of lactoferrin(LF),prostaglandin E2(PGE2)and receptor activator of nuclear factor-κB(NF-κB)ligand(RANKL)in the observation group were(154.12±15.12)ng/L,(87.10±10.20)ng/L and(58.17±7.17)g/L,which were significantly lower than(172.09±17.02)ng/L,(96.31±11.05)ng/L and(66.92±8.10)g/L in the control group(t=5.722,4.439,5.864,P=0.000,0.000,0.000).The scores of mastication,pronunciation and swallowing in the observation group were(7.95±1.97)points,(8.18±1.81)points and(8.54±1.57)points respectively,which were significantly higher than(6.82±1.86)points,(7.41±1.66)points and(7.48±
作者
刘书钗
王美
张楠
LIU Shuchai;WANG Mei;ZHANG Nan(Hengshui Second People's Hospital,Hengshui,Hebei,China 053000)
出处
《中国药业》
CAS
2021年第23期93-96,共4页
China Pharmaceuticals
基金
河北省医学科学研究重点课题[20201211]。
关键词
慢性牙周炎
牙列缺损
康复新液
种植义齿修复术
咀嚼功能
临床疗效
chronic periodontitis
dentition defect
Kangfuxin Liquid
implant denture restoration
masticatory function
clinical efficacy
