摘要
目的:探讨河南农村成年男性和绝经女性血清黄体酮浓度与肥胖的关联性。方法:研究对象来自河南农村队列,根据纳排标准,共纳入4862名研究对象,其中成年男性2574人,绝经女性2288人。采用液相色谱-串联质谱法检测血清黄体酮浓度,运用线性回归模型分析成年男性和绝经女性人群中血清黄体酮浓度与肥胖指标BMI、腰围(WC)、腰臀比(WHR)、腰身比(WHtR)的关联,应用Logistic回归模型和限制性立方样条图分析血清黄体酮浓度与肥胖患病危险性的关联性及其剂量反应关系。结果:调整年龄、文化程度、婚姻状况、人均月收入、吸烟情况、饮酒情况、较多蔬菜水果摄入、高脂饮食、体力活动后,血清黄体酮浓度与BMI、WC、WHR、WHtR呈正相关(P<0.05);与BMI、WC、WHR、WHtR定义的肥胖风险相关,男性OR(95%CI)分别为1.23(1.01~1.50)、1.23(1.09~1.40)、1.20(1.08~1.33)、1.20(1.08~1.33),女性OR(95%CI)分别为1.18(1.00~1.39)、1.27(1.15~1.40)、1.25(1.14~1.38)、1.25(1.13~1.38)。限制性立方样条图分析结果显示,男性血清黄体酮浓度与无论何种指标定义的肥胖均存在线性剂量反应关系(P<0.05);对于女性,只有当肥胖由WHtR定义时,两者之间存在线性剂量反应关系。结论:河南农村人群成年男性和绝经女性肥胖的发生与血清黄体酮浓度有关联。
Aim:To explore the relationship between progesterone and obesity in male adults and postmenopausal women from Henan rural areas.Methods:Individuals of the study were derived from the Henan rural cohort study.According to the inclusion and exclusion criteria,4862 individuals were chosen,including 2574 male adults and 2288 postmenopausal women.The concentration of serum progesterone was measured by liquid chromatography-tandem mass spectrometry.The association between serum progesterone and obesity indexes such as BMI,waist circumference(WC),waist-to-hip ratio(WHR)and waist to height ratio(WHtR)was tested by multivariable linear regression.The Logistic regression and the restricted cubic spline were used to examine the relationship between serum progesterone and the risk of obesity and its dose response,respectively.Results:After adjusting for age,education level,marital status,per capita monthly income,smoking,alcohol consumption,higher intake of fruits and vegetables,high-fat diet,physical activity,serum progesterone concentration was positively related with BMI,WC,WHR,and WHtR(P<0.05);it was also significantly associated with obesity risk when obesity was defined by BMI,WC,WHR and WHtR,respectively,OR(95%CI)for male adults was 1.23(1.01-1.50),1.23(1.09-1.40),1.20(1.08-1.33),1.20(1.08-1.33),and those for the females was 1.18(1.00-1.39),1.27(1.15-1.40),1.25(1.14-1.38),1.25(1.13-1.38).The results of the restricted cubicspline show that there was a dose response relationship between male progesterone level and obesity defined by any indicator,and a dose response relationship between the females progesterone level and obesity only defined by WHtR.Conclusion:The serum progesterone concentration may be associated with the increased risk of obesity in male adults and postmenopausal women from Henan rural areas.
作者
刘月婷
黄金娇
孙家琦
刘欢
刘道瀚
聂璐婷
毛振兴
霍文倩
LIU Yueting;HUANG Jinjiao;SUN Jiaqi;LIU Huan;LIU Daohan;NIE Luting;MAO Zhenxing;HUO Wenqian(Department of Environmental Health,College of Public Health,Zhengzhou University,Zhengzhou 450001;Department of Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou 450001)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2021年第6期779-784,共6页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金项目(21806146)
国家博士后科学基金项目(2016M602264,2020T130604)
河南省科技厅重点研发与推广专项科技攻关项目(202102310074)
河南省级大学生创新创业训练计划项目(S202010459154)
郑州大学青年骨干教师项目(2018ZDGGJS052)。
关键词
黄体酮
肥胖
河南农村
成年男性
绝经女性
progesterone
obesity
Henan rural area
male adult
postmenopausal women
