摘要
目的研究异常凝血酶原联合甲胎蛋白(AFP)异质体在乙肝相关性肝癌中的临床意义。方法选取2019年1月至2020年12月于萍乡市第二人民医院门诊及住院的20例肝硬化患者作为肝硬化组,另选取同期收治的40例乙肝相关性肝癌患者作为乙肝相关性肝癌组。对所有患者进行血清AFP、AFP异质体及异常凝血酶原水平的检测。比较乙肝相关性肝癌组与肝硬化组患者的血清AFP、AFP异质体、异常凝血酶原水平、各项的阳性率及单一与三者联合检测的诊断价值。结果乙肝相关性肝癌组患者的血清AFP、AFP异质体、异常凝血酶原水平及各项指标阳性率均高于肝硬化组,乙肝相关性肝癌组患者的异常凝血酶原阳性率高于AFP,差异有统计学意义(P<0.05)。三者联合检测的特异度高于异常凝血酶原,敏感度与准确度均高于AFP、AFP异质体单一检测,差异有统计学意义(P<0.05)。结论肝癌患者的血清AFP、AFP异质体、异常凝血酶原水平及阳性率均高于肝硬化患者,乙肝相关性肝癌组患者的异常凝血酶原阳性率高于AFP,且临床上通过三者联合检测可提高肝癌筛查的阳性率,进而有助于对肝癌的早期诊断。
Objective To study the clinical significance of abnormal prothrombin combined with alpha-fetoprotein(AFP)heterogeneity in hepatitis B related liver cancer.Methods From January 2019 to December 2020,20 outpatients and inpatients with liver cirrhosis in the Second People′s Hospital of Pingxiang City were selected as the liver cirrhosis group,and another 40 patients with hepatitis B related liver cancer admitted to hospital during the same period were selected as hepatitis B related liver cancer group.The levels of serum AFP,AFP heterogeneity and abnormal prothrombin were detected in all patients.The positive rates of serum AFP,AFP heterogeneity and other items,and the diagnostic value of single and combined detection were compared between hepatitis B related liver cancer group and liver cirrhosis group.Results The levels and positive rates of serum AFP,AFP heterogeneity and abnormal prothrombin in hepatitis B related liver cancer group were higher than those in liver cirrhosis group,the positive rate of abnormal prothrombin in hepatitis B related liver cancer group was higher than that of AFP,and the differences were statistically significant(P<0.05).The specificity of the combined detection of the three was higher than that of abnormal prothrombin,and the sensitivity and accuracy were higher than that of AFP and AFP heterosomes alone,the differences were statistically significant(P<0.05).Conclusion The levels and positive rate of serum AFP,AFP heterogeneity and abnormal prothrombin in patients with liver cancer are higher than those in patients with liver cirrhosis.The positive rate of abnormal prothrombin in hepatitis B related liver cancer group was higher than that of AFP.Combined detection of AFP heterogeneity and abnormal prothrombin can improve the positive rate of liver cancer screening,which is helpful for the early diagnosis of liver cancer.
作者
邱艳
赖娟
占魁
QIU Yan;LAI Juan;ZHAN Kui(Department of Infectious Diseases,the Second People′s Hospital of Pingxiang City,Jiangxi Province,Pingxiang,337000,China)
出处
《中国当代医药》
CAS
2021年第33期173-175,共3页
China Modern Medicine
基金
江西省萍乡市科技计划项目(2019PY110)。
关键词
乙肝
肝癌
异常凝血酶原
甲胎蛋白异质体
临床意义
Hepatitis B
Liver cancer
Abnormal prothrombin
Alpha-fetoprotein heterogeneity
Clinical significance
