摘要
自体脂肪移植已经被广泛应用于临床,但存活率低。联合注射富血小板血浆(PRP)可作为提高脂肪移植存活率的策略之一,其可能通过促进移植脂肪的血管化、提高脂肪干细胞的增殖与分化能力、调节炎症等机制促进脂肪存活。学者们开展了PRP联合自体脂肪移植的多项临床应用研究,其中许多研究表明PRP可促进血管生成、提高脂肪移植物保留率等,但其疗效仍存争议。该文介绍了自体脂肪移植概况以及PRP的作用机制,着重对PRP联合自体脂肪移植的临床试验进行了比较与分析,旨在为提高PRP在自体脂肪移植手术中的应用效果提供参考和依据。
Autologous fat grafting has been widely used in clinical surgeries in recent years,while the low survival rate of the graft is an important limitation.Platelet-rich plasma(PRP)is one of the strategies to improve the survival rate of the graft.PRP may promote the survival of the graft by stimulating the vascularization of transplanted fat,enhancing the proliferation and differentiation ability of adipose stem cells,and regulating inflammation.Many clinical studies have been carried out using PRP together with autologous fat grafting,revealing that PRP may promote angiogenesis and fat graft retention,but the effectiveness remains controversial.To provide reference and basis for improving the effectiveness of PRP in autologous fat grafting,we introduced the autologous fat grafting and the mechanism of PRP,analyzed clinical trials of PRP combined with autologous fat grafting in this article.
作者
魏斌
王长琛
范金财
Wei Bin;Wang Changchen;Fan Jincai(The First Department of Surgery,Beijing Armed Police Corps Hospital,Beijing 100027,China;The Ninth Department of Plastic Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144,China)
出处
《中华整形外科杂志》
CSCD
2021年第10期1175-1180,共6页
Chinese Journal of Plastic Surgery
