摘要
Multiple sclerosis(MS)is a neurological condition characterized by the disruption of the blood-brain barrier,immune system activation,and infla mmation that is accompanied by glial reactivity,neuronal cell death,axon demyelination,and axotomy.Pathological changes result in functional loss including paralysis,migraine,vision problems,spasticity,and neuropathic pain.
基金
supported by The John M.and Jocelyn H.K.Watkins Distinguished Chair in Cell Therapies(to DDP)
The Miami Project to Cure Paralysis and The Buoniconti Fund(to DDP and MG)。
