摘要
目的:评价并比较选择性激光小梁成形术(SLT)治疗不同分期原发性开角型青光眼(POAG)的临床效果。方法:回顾性研究。选取2018-07/2020-03在我院选择行SLT治疗POAG患者27例51眼,按照视野平均缺损(MD)将患者分三组:早期组(MD>-6dB)15眼,中期组(-12dB≤MD≤-6dB)15眼,晚期组(MD<-12dB)21眼,采用532nm倍频Q开关Nd∶YAG激光治疗仪,脉冲时间3ns,光斑直径400μm,行360°SLT治疗,观察治疗后1h,1d,1、3、6、12mo眼压下降比例,观察视野指数(VFI)及MD变化、用药变化、不良反应及治疗有效率。结果:治疗后12mo内,三组患者眼压及眼压下降比例组间比较均无差异(均P>0.05),各组间VFI及MD有差异(P<0.001),随观察时间延长,各组VFI及MD均未见明显下降(P>0.05)。三组患者治疗有效率在治疗后1、3、6、12mo分别为早期组(100%、93%、87%、67%),中期组(87%、80%、93%、60%),晚期组(67%、71%、62%、19%)。结论:SLT对早期组、中期组、晚期组POAG患者均可实现有效治疗,但治疗有效率随着时间延长而降低。
AIM:To assess and compare the effectiveness of selective laser trabeculoplasty(SLT)in preventing primary open angle glaucoma(POAG)with various stages.METHODS:Fifty-one eyes of 27 patients 51 eye with POAG were included in this retrospective study.All the cases were divided into three groups depending on the mean deviation(MD):the early stage group(MD>-6dB,15 eyes),middle stage group(-12dB≤MD≤-6dB,15 eyes)and late stage group(MD<-12dB,21 eyes).All subjects underwent SLT on 360°of the angle between July 2018 to March 2020.The laser parameters of a 532nm,Q-switched,frequency-doubled Nd∶YAG laser,with 3ns pulse time,400μm spot diameter were set to selectively target pigmented trabecular meshwork cells without visible damage to the adjacent non-pigmented tissue.Intraocular pressure(IOP)reduction was observed at 1h,1d,1,3,6 and 12mo after the laser procedure.Meanwhile,the ratio of the IOP reduction,visual field index(VFI),MD,medication,adverse reactions and efficiency were assessed as well.RESULTS:Within the 12mo post-SLT,there were no statistically significant differences for the IOP and IOP decline rate between each group(all P>0.05).There were significant differences in VFI and MD among early,middle and late groups(P<0.001),within the 12mo post-SLT,no statistically significant differences were detected for the decline of VFI and MD in each group.In terms of the early stage group,the effective rates of SLT at 1,3,6 and 12mo after treatment were 100%,93%,87%,67%,respectively.For the middle stage group and late stage group,the effective rates were 87%,80%,93%,60%,and 67%,71%,62%,19%,respectively.CONCLUSION:SLT was an effective treatment for POAG patients in various stages,while the effective rate decreased with time.
作者
周宇
武明星
李兰娇
Yu Zhou;Ming-Xing Wu;Lan-Jiao Li(Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China)
出处
《国际眼科杂志》
CAS
北大核心
2021年第12期2113-2117,共5页
International Eye Science
基金
国家自然科学基金青年科学基金项目(No.81901765)。
关键词
选择性激光小梁成形术
原发性开角型青光眼
眼压
selective laser trabeculoplasty
primary open angle glaucoma
intraocular pressure
