摘要
他汀类药物通过甲羟戊酸途径影响胆固醇代谢,可以有效防治心脑血管疾病,是抗动脉粥样硬化的一线用药。近年来随着他汀的广泛应用,药品不良反应的相关报道也逐渐增多。其中,骨骼肌相关不良反应是导致患者用药依从性下降的首要原因,造成药效不能保证,不仅增加了心脑血管事件发生率,还严重影响患者肌肉强度和日常生活活动能力。文章就他汀相关肌肉症状(statin-associated muscle symptoms,SAMS)和他汀相关自身免疫性肌病作一综述,以期为临床提供一定的参考。
Statins inhibit the critical step of cholesterol synthesis via the mevalonate pathway,can effectively prevent cardio cerebrovascular disease,and are the first-line medication against atherosclerosis.Along with the extensive usage of statin therapy,the adverse reactions of the drug is gradually increasing clinical report.The adverse effects specifically related to skeletal muscle,is one of the primary reason that leads to the decrease of patients'medication compliance,as a result,the efficacy cannot be guaranteed,which not only increases the incidence of cardiovascular and cerebrovascular events,but also seriously affects the patients'muscle strength and ability of daily activities.This review introduces the research advance on statin-associated muscle symptoms(SAMS)and statin-related autoimmune myopathy,in order to provide some practical significance for clinical medicine.
作者
张永锋
段瑞生
Zhang Yongfeng;Duan Ruisheng(Department of Neurology,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan 250014,China;Department of Neurology,the First Affiliated Hospital of Shandong First Medical University Department of Neurology,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan 250014,China)
出处
《国际免疫学杂志》
CAS
2021年第4期440-447,共8页
International Journal of Immunology
基金
山东第一医科大学学术提升计划(2019QL013)。
关键词
他汀类药物
肌肉症状
免疫性肌病
Statins
Muscle symptoms
Immune inflammatory myopathy
