摘要
钛及其合金具有稳定的化学性质和良好的人体亲和性,常被作为骨科植入材料,但未经处理的钛植入物易发生骨整合不良和植入物周围感染导致植入失败。近年来,人口老龄化加剧带动植入材料使用量增加,亟需性能更好的钛表面修饰方法以降低植入失败率。理想的骨科植入物应同时具备促成骨和抗菌特性,但目前大量表面改性策略只解决其中一种问题,导致植入物无法达到预期效果。因此,植入材料涂层需满足这两种特性或在两者间寻找平衡点。综述近几年来解决钛植入物无菌性松动或感染问题的最新策略,如表面形貌改善和生物分子涂层等促进成骨,抗菌药物负载和光热治疗等防治感染措施,并通过双因素整合和三因素整合进一步介绍了同时解决这两个问题的研究进展。
Titanium and its alloys are often used as orthopedic implant materials because of their stable chemical properties and good human affinity.However,untreated titanium implants are prone to poor osseointegration and infection,resulting in implantation failure.In recent years,the aging of population has led to an increase in the use of implant materials,and there is an urgent need for better titanium surface modification methods to reduce the implant failure rate.The ideal orthopedic implant should have both osteogenic and antibacterial properties.However,a large number of surface modification strategies only solve one of the problems,resulting in unexpected results.Therefore,the implant material coating needs to possess both two properties or find a balance between them.This review summarized the latest strategies to solve the problem of aseptic loosening or infection of titanium implants in recent years,such as surface morphology improvement,biomolecule coatings,antimicrobial loading,photothermal therapy and so on.Then,we further introduced the research progress of solving these two problems at the same time through two-factor integration and three-factor integration.
作者
陆肖璇
张露露
阳曦
陈佳龙
Lu Xiaoxuan;Zhang Lulu;Yang Xi;Chen Jialong(Key Lab of Oral Diseases Research of Anhui Province,Stomatologic Hospital&College,Anhui Medical University,Hefei 230032,China)
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2021年第5期620-627,共8页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金(31670967)
安徽省转化医学研究院科研基金(2017zhyx19)
安徽省高等学校省级质量工程项目(2019jyxm0138)。
关键词
骨科植入物
骨整合
抗感染
钛
orthopaedic implants
osseointegration
antimicrobial
titanium
