摘要
目的探究党黄抗癌汤结合体腔热灌注化疗治疗卵巢癌并腹腔积液临床疗效及安全性。方法研究合计纳入93例卵巢癌并腹腔积液患者,均由医院2018年6月—2020年1月收治,采取随机数字表法将其分为对照组与观察组,对照组患者(46例)采取体腔热灌注化疗治疗,观察组患者(47例)采取党黄抗癌汤结合体腔热灌注化疗治疗,比较两组患者临床疗效、治疗前后患者中医症状(腹胀腹痛、神疲乏力、小便难少、纳少便溏等)积分变化、癌胚抗原(CEA)水平变化、免疫球蛋白(IgA、IgG、IgM)与T淋巴细胞亚群(CD_(3)^(+)、CD_(4)^(+))等免疫功能指标变化、Karnofsky评分(KPS)指标变化、不良反应情况。结果观察组疗效优于对照组,P<0.05;治疗前,两组患者腹胀腹痛、神疲乏力、小便难少、纳少便溏等中医症状积分、CEA水平、IgA、IgG、IgM及CD+3、CD+4等免疫功能指标、KPS生活质量量表评分比较,P>0.05,治疗后各组患者腹胀腹痛、神疲乏力、小便难少、纳少便溏等中医症状积分、CEA水平、IgA、IgG、IgM及CD_(3)^(+)、CD_(4)^(+)等免疫功能指标、KPS生活质量量表评分均改善,观察组患者治疗后腹胀腹痛、神疲乏力、小便难少、纳少便溏等中医症状积分、CEA水平、IgA、IgG、IgM及CD_(3)^(+)、CD_(4)^(+)等免疫功能指标、KPS生活质量量表评分优于对照组患者(P<0.05);两组患者治疗过程中均出现一定程度恶心呕吐、皮疹、头晕头痛、脱发、骨髓抑制、肝肾功能异常、周围神经病变、血小板降低等化疗不良反应,经处理可缓解(P>0.05)。结论党黄抗癌汤结合体腔热灌注化疗治疗卵巢癌并腹腔积液疗效显著,可较好改善患者症状,提升患者免疫功能,抑制癌细胞扩散,虽存在不良反应,但患者可耐受,值得临床应用。
e Objective To explore the clinical efficacy and safety of Danghuang Kang'ai Decoction(党黄抗癌汤)combined with intracavitary hyperthermic perfusion chemotherapy for ovarian cancer with peritoneal effusion.s Methods The study included 93 patients with ovarian cancer and abdominal cavity effusion in our hospital from June 2018 to January 2020.By the random number table method,the patients were divided into control group and observation group.The control group(46 cases)used int-racavitary hyperthermic perfusion chemotherapy and the observation group(47 cases)was treate dwith Danghuang Kang'ai Decoc-tion combined with intracavitary hyperthermic perfusion chemotherapy.We compared two groups’clinical curative effect,TCM symptoms integral(abdominal distension,abdominal pain,fatigue,less urine,loose stools,etc.),levels of carcinoembryonic an-tigen(CEA),immunoglobulin(IgA,IgG,IgM)and T lymphocyte subsets(CD_(3)^(+),CD_(4)^(+)),Karnofsky score(KPS)changes and adverse reaction conditions.s Results The effect of the observation group was better than that of the control group(P<0.05).Be-fore treatment,two groups’TCM symptoms integral(abdominal distension,abdominal pain,fatigue,less urine,loose stools),levels of CEA,IgA,IgG,IgM,CD_(3)^(+),CD_(4)^(+) and other immune function indexes,and KPS were not significant(P>0.05).The treatment group’s TCM symptoms integral(abdominal distension,abdominal pain,fatigue,less urine and loose stools),levels of CEA,IgA,IgG,IgM,CD_(3)^(+),CD_(4)^(+) and other immune function indexes and KPS were improved,After treatment,patients in the observation group were better than those in the control group in terms of TCM symptom scores,levels of CEA,IgA,IgG,IgM,CD_(3)^(+),CD_(4)^(+) and other immune function indicators and KPS(P<0.05).During the treatment,nausea and vomiting,skin rash,dizziness and headache,hair loss,bone marrow suppression,abnormal liver and kidney function,peripheral neuropathy,throm-bocytopenia and other chemotherapy side effects occurred in both groups,which could be alle
作者
芮永
彭宓娜
RUI Yong;PENG Mina(Hefei Cancer Hospital,Chinese Academy of Sciences,Hefei 230031,Anhui,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第10期227-230,共4页
Chinese Archives of Traditional Chinese Medicine
基金
安徽省科技厅科技计划年度重点项目(12070403075)。
关键词
卵巢癌并腹腔积液
党黄抗癌汤
体腔热灌注化疗
疗效
免疫功能
不良反应
ovarian cancer with peritoneal effusion
Danghuang Kang'ai Decoction(党黄抗癌汤)
intracavitary hyperthermic perfusion chemotherapy
curative effect
immune function
adverse reaction
