摘要
目的探讨肿瘤特异性生长因子(TSGF)、鳞状上皮细胞癌抗原(SCC-Ag)、糖类抗原-125(CA125)水平对宫颈癌病情监测及预后评估的价值。方法选取我院2016年2月至2017年3月收治的86例宫颈癌患者(宫颈癌组)、46例宫颈上皮内瘤变患者(良性组)和40例健康体检女性(对照组)作为研究对象,检测三组受试者血清TSGF、SCC-Ag、CA125的水平。并在结束治疗后随访3年,根据肿瘤是否复发,将86例宫颈癌患者分为复发组22例和未复发组64例,比较两组TSGF、SCC-Ag、CA125水平,分析以上3项指标单项及联合检测对宫颈癌病情及预后的评估价值。结果宫颈癌组血清TSGF、SCC-Ag、CA125水平均高于良性组和对照组,差异有统计学意义(P<0.05);随访3年内复发组血清TSGF、SCC-Ag、CA125水平均明显高于未复发组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,患者血清TSGF、SCC-Ag、CA125水平与治疗后3年内复发呈正相关(r=0.536、0.328、0.745,P<0.05)。ROC曲线分析显示,患者血清TSGF+SCC-Ag+CA125水平联合预测其3年内肿瘤复发的灵敏度、特异度及准确性均较高,差异有统计学意义(P<0.05)。结论血清TSGF、SCC-Ag、CA125水平有助于准确地监测宫颈癌患者的病情程度,三项指标联合检测可作为患者预后的评估指标,具有一定的临床价值。
Objective To explore the value of tumor specific growth factor(TSGF),squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen-125(CA125)levels in cervical cancer monitoring and prognostic evaluation.Methods A total of 86 patients with cervical cancer(cervical cancer group),46 patients with cervical intraepithelial neoplasia(benign group)and 40 healthy women(control group)who were admitted to our hospital from February 2016 to March 2017 as the research subjects.The levels of serum TSGF,SCC-Ag,and CA125 in the three groups were detected.After the treatment,the patients were followed up for three years.According to whether the tumor recurred,86 patients with cervical cancer were divided into the recurrence group of 22 cases and the non-recurrence group of 64 cases.The levels of TSGF,SCC-Ag and CA125 between the two groups were compared.The evaluation value of single and combined tests of the above three indicators on the condition and prognosis of cervical cancer were analyzed.Results The serum TSGF,SCC-Ag,CA125 levels in cervical cancer group were higher than those in benign group and control group,and the difference was statistically significant(P<0.05).The serum TSGF,SCC-Ag,CA125 levels in recurrence group within three years of follow-up were significantly higher than the non-recurrence group,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that serum TSGF,SCC-Ag,and CA125 levels were positively correlated with recurrence within three years after treatment(r=0.536,0.328,0.745,P<0.05).ROC curve analysis showed that the sensitivity,specificity,and accuracy of the combination of serum TSGF+SCC-Ag+CA125 levels in predicting tumor recurrence within three years were higher,and the difference was statistically significant(P<0.05).Conclusion Serum TSGF,SCC-Ag,and CA125 levels are helpful to accurately monitor the severity of cervical cancer patients.The combined detection of the three indicators can be used as an evaluation indicator for the prognosis of patients and has
作者
高志洪
钱丽萍
GAO Zhihong;QIAN Liping(Department of Laboratory Medicine,Wujin Hospital Affiliated to Jiangsu University,Changzhou 213000,China;Maternity and Child Health and Family Planning Service Center of Xinbei District of Changzhou City in Jiangsu Province,Changzhou 213000,China)
出处
《中国现代医生》
2021年第27期13-16,33,共5页
China Modern Doctor
