摘要
目的:探讨全胸腔镜肺叶切除术对肺癌患者磷脂酰肌醇-3激酶(PI3K)、Notch信号通路-1(Notch-1)水平的影响。方法:选取2018年1月-2020年1月本院收治的96例肺癌患者为研究对象,将其随机分为观察组和对照组,各48例。对照组给予开放式手术治疗,观察组行全胸腔镜肺叶切除术治疗。比较两组手术相关指标、并发症发生情况、肿瘤标志物水平、PI3K、Notch-1水平、生存情况。结果:观察组手术时间、术后排气时间、开始下床活动时间、住院时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05)。观察组术后并发症发生率为8.33%,低于对照组的25.00%,差异有统计学意义(P<0.05)。术后,两组CYFRA21-1、NSE、LTA、PI3K、Notch-1水平均低于术前,且观察组CYFRA21-1、NSE、LTA、PI3K、Notch-1水平均低于对照组,差异均有统计学意义(P<0.05)。经过为期12个月的随访,观察组PFS、OS均长于对照组,差异均有统计学意义(P<0.05)。结论:全胸腔镜肺叶切除术能提高肺癌患者的手术效果,降低患者的手术损伤,提高手术安全性,降低肿瘤标志物水平和PI3K、Notch-1水平,一定程度上延长患者的生存周期,可在临床实践中推广应用。
Objective:To investigate the effects of total thoracoscopic lobectomy on the levels of phosphatidylinositol-3 kinase (PI3K) and Notch signaling pathway-1 (Notch-1) in patients with lung cancer.Method:A total of 96 lung cancer patients admitted to our hospital from January 2018 to January 2020 were selected as the research objects,and they were randomly divided into observation group and control group,48 cases in each group.The control group was treated with open surgery,the observation group was treated with thoracoscopic lobectomy.The surgery related indicators,incidence of complications,tumor marker levels,PI3K,Notch-1 levels and survival situation were compared between the two groups.Result:The observation group had shorter surgery time,postoperative exhaust time,time to get out of bed and hospital stay than those in the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant (P<0.05).The incidence of postoperative complications in the observation group was 8.33%,lower than 25.00% in the control group,the difference was statistically significant (P<0.05).After surgery,the levels of CYFRA21-1,NSE,LTA,PI3K and Notch-1 in the two groups were lower than those before surgery,and the levels of CYFRA21-1,NSE,LTA,PI3K and Notch-1 in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).After 12 months of follow-up,PFS and OS in the observation group were longer than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Total thoracoscopic lobectomy can improve the surgical effect of lung cancer patients,reduce the surgical injury of patients,improve the safety of surgery,reduce the level of tumor markers and PI3K,Notch-1,and prolong the survival cycle of patients to a certain extent,which can be popularized and applied in clinical practice.
作者
孙宏建
SUN Hongjian(Jiamusi Central Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2021年第30期20-24,共5页
Medical Innovation of China
