摘要
目的:探究自拟疏风清热凉血方治疗风热之邪所致肾性血尿的临床价值。方法:选取2018年6月~2020年8月到我院肾病科就诊的肾性血尿(风热伤络证)患者86例,采用随机数字表法将其分为研究组和对照组各43例。给予对照组百令胶囊及肾性血尿的常规治疗;在对照组的基础上给予研究组自拟疏风清热凉血方治疗。比较两组治疗前及治疗8周时的肾功相关指标[血尿素氮(BUN)、血肌酐(Scr)、肾小球滤过率(GFR)]水平、血清相关蛋白[β2微球蛋白(β2-MG)、视黄醇结合蛋白(RBP)、胱抑素C(CysC)]含量、尿液肾损伤标志物[肾损伤分子1(KIM-1)、单核细胞趋化蛋白1(MCP-1)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)]水平变化及尿检结果(尿沉渣红细胞数、24h尿蛋白定量);比较两组治疗8周时的中医证候积分。结果:治疗8周时,两组肾功能相关指标(BUN、Scr、GFR)较治疗前均明显改善,且研究组显著优于对照组(P均<0.05);两组血清β2-MG、RBP含量于治疗8周时明显降低,且研究组显著低于对照组(P均<0.05),两组血清CysC水平虽于治疗后明显下降,但组间无统计学意义(P>0.05);治疗8周时,两组尿液肾损伤标志物(KIM-1、MCP-1、NGAL)水平及尿检结果(尿沉渣红细胞数、24h尿蛋白定量)较治疗前明显降低,且研究组显著低于对照组(P均<0.05);研究组治疗8周时的中医证候(口干咽燥、恶风发热、五心烦热、倦怠乏力)积分显著低于对照组(P均<0.05)。结论:疏风清热凉血方对因风热之邪所致的肾性血尿患者有良好应用效果。
Objective:To explore the clinical value of using Self-made Shufeng Qingre Liangxue Prescription in treating renal hematuria caused by wind-heat syndrome.Methods:A total of 86 patients with renal hematuria(wind-heat involving collateral syndrome)who were treated in the department of nephrology of our hospital were selected between June 2018 and August 2020,and they were divided into a study group and a controlled group by the random number table method,with 43 cases in each group.The controlled group was given Bailing Capsules and conventional treatment of renal hematuria,and the study group was given Self-made Shufeng Qingre Liangxue Prescription on the basis of the controlled group.The renal function-related indexes[blood urea nitrogen(BUN),serum creatinine(Scr),glomerular filtration rate(GFR)],serum related proteins[β2 microglobulin(β2-MG),retinol binding protein(RBP),cystatin C(CysC)],urine kidney injury markers[kidney injury molecule 1(KIM-1),monocyte chemoattractant protein 1(MCP-1),neutrophil gelatinase-associated lipocalin(NGAL)]and urine test results(urinary sediment red blood cell count,24 h urine protein quantification)were compared between the two groups before treatment and at 8 weeks of treatment.The TCM syndrome scores of the two groups at 8 weeks of treatment.Results:At 8 weeks of treatment,the renal function-related indexes(BUN,Scr,GFR)of the two groups were significantly improved compared with those before treatment,and the indexes of the study group were significantly better than those of the controlled group(all P<0.05).The levels of serumβ2-MG and RBP in the two groups were significantly reduced at 8 weeks of treatment,and the levels in the study group were significantly lower than those in the controlled group(all P<0.05),and the level of serum CysC of the two groups was decreased significantly after treatment,but there was no statistical significance between the groups(P>0.05).At 8 weeks of treatment,the levels of urine kidney injury markers(KIM-1,MCP-1,NGAL)and urine test results(urinary
作者
李树纲
刘红霞
胡俊波
姚玉婷
于涛
LI Shugang;LIU Hongxia;HU Junbo(Department of Respiratory and Nephrology,Dunhuang Municipal Hospital,Dunhuang Gansu 736200,China)
出处
《四川中医》
2021年第9期113-117,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
甘肃省青年科技基金计划项目(编号:20JR10RF816)。
关键词
疏风清热凉血方
肾性血尿
肾功能
肾损伤分子1
尿沉渣红细胞数
临床疗效
Shufeng Qingre Liangxue prescription
Renal hematuria
Renal function
Kidney injury molecule 1
Urine sediment red blood cell count
Clinical efficacy
