摘要
肿瘤坏死因子α诱导蛋白8样蛋白(TIPE/TNFAIP8)家族是新近发现的一个与免疫调节和肿瘤发生密切相关的蛋白家族。该家族由4个成员组成,即肿瘤坏死因子α诱导蛋白8样蛋白(TIPE/TNFAIP8)、肿瘤坏死因子α诱导蛋白8样蛋白1(TIPE1/TNFAIP8L1)、肿瘤坏死因子α诱导蛋白8样蛋白2(TIPE2/TNFAIP8L2)和肿瘤坏死因子α诱导蛋白8样蛋白3(TIPE3/TNFAIP8L3)。尽管这个家族的4个成员之间存在着显著的序列同源性,但它们参与了不同的生物学活动,并且表现出显著的表达差异性。此外,该蛋白家族在不同的人类肿瘤中表达高度不一致,且生物学功能在不同肿瘤类型中表现出多样性及复杂性。本文从近几年来TIPE家族与肿瘤系统研究的文献中,总结了TIPE蛋白家族在不同类型肿瘤中的重要作用及其与各种信号传导通路的关系,以期为后续研究提供一定的理论与实践基础。
Tumor necrosis factor-α-inducible protein 8-like(TIPE/TNFAIP8)family is a newly discovered protein family that is closely related to immune regulation and tumorigenesis.The family consists of four members:Tumor necrosis factor alpha inducible protein 8(TIPE/TNFAIP8),tumor necrosis factor alpha inducible protein 8 like protein 1(TIPE1/TNFAIP8 L1),tumor necrosis factor alpha inducible protein 8 like protein 2(TIPE2/TNFAIP8 L2)and tumor necrosis factor alpha inducible protein 8 like protein 3(TIPE3/TNFAIP8 L3).Although there are significant sequence homologies among the four members of this family,they participate in different biological activities and show different expression pattern in types of cancers.In addition,the expression of this family is highly inconsistent in different human tumors,and the biological function shows diversity and complexity in different tumor types as well.From the literature on TIPE family in recent years,this paper summarizes the important role of TIPE protein family in different types of tumors and its relationship with various signal transduction pathways,in order to provide some theoretical and practical basis for follow-up researches.
作者
杨秀珍(综述)
赵培庆(指导/审阅)
YANG Xiu-Zhen;ZHAO Pei-Qing(Department of Clinical Laboratory,Zibo Central Hospital,Zibo 255036,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2021年第21期2640-2646,2652,共8页
Chinese Journal of Immunology
基金
国家自然科学基金面上项目(81972002)
山东省自然科学基金面上项目(ZR2019MH099)资助。
