摘要
TIPE(Tumor necrosis factor-alpha-induced protein 8-like)家族是新近报道的免疫和肿瘤调节因子。该家族拥有四个高度同源的成员:TNFAIP8(Tumor necrosis factor-α-induced protein 8),TIPE1(TNFAIP8L1),TIPE2(TNFAIP8L2)和TIPE3(TNFAIP8L3)。它们虽然结构相似,但在组织、器官上的表达不同,在生物学功能及疾病中的作用存在较大的差别。TNFAIP8具有抑制细菌感染与促肿瘤迁移的作用;TIPE2是一种免疫和炎症负调控因子,可抑制某些肿瘤的生长;TIPE1可诱导细胞凋亡具有抑瘤效应;TIPE3可特异性结合磷脂第二信使,促进肿瘤生成。随着研究的深入,TIPE家族在多种疾病的发生发展过程中表现出重要的调控作用,然而其具体生物活性与分子机制有待进一步的研究。
The TIPE（ tumor necrosis factor-alpha-induced protein 8-like） family has been recently described as regulators of tumorigenesis and inflammation. The family consists of four highly homologous members： TNFAIP8（ tumor necrosis factor-α-induced protein 8）,TIPE1（ TNFAIP8L1）,TIPE2（ TNFAIP8L2） and TIPE3（ TNFAIP8L3）. Although TNFAIP8 family share high degrees of sequence homology,the members have different histological expressions,biological functions and molecular targets. TNFAIP8 shows the functions of inhibiting bacterial infection and promoting tumor migration. As a negative regulator of immunity and inflammation,TIPE2 is also an inhibitor of the oncogenic Ras in some neoplastic diseases. TIPE1 can induce cell apoptosis and inhibit tumor. TIPE3 is the transfer protein of phosphoinositide second messengers and can promote cancer. Emerging studies show TIPE family play important regulatory roles in many diseases; however,specific biological activities and exact molecular mechanisms need to be further elucidated.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第8期1089-1093,共5页
Chinese Journal of Immunology
