摘要
目的研究帕金森病患者血清巨噬细胞游走抑制因子(MIF)、脑源性神经营养因子(BDNF)及尿阿尔茨海默病相关神经丝蛋白(AD7c-NTP)表达水平与认知功能损伤的相关性。方法选择2018年2月~2020年2月在我院门诊就诊和住院收治的帕金森病患者115例为研究组,同期选择正常健康者118例为对照组,比较两组患者一般资料及血清MIF、BDNF及尿AD7c-NTP水平。采用简易精神状态量表(MMSE)对研究组患者认知功能进行评估,根据结果分为轻度、中度、重度认知功能损伤组,并比较各组患者脑区平均弥散率(MD)、各向异性分数(FA)值定量范围及血清MIF、BDNF、尿AD7c-NTP水平。结果研究组患者MMSE评分显著低于对照组(P<0.05);研究组患者血清MIF、尿AD7c-NTP水平高于对照组,血清BDNF水平低于对照组,均差异有统计学意义(P<0.05)。3组患者FA、MD值水平差异有统计学意义(P<0.05);重度组患者血清MIF、尿AD7c-NTP水平显著高于中度组、轻度组(P<0.05),血清BDNF水平低于中度组、轻度组(P<0.05);中度组患者血清MIF、尿AD7c-NTP水平显著高于轻度组(P<0.05),血清BDNF水平低于轻度组(P<0.05)。患者血清MIF、尿AD7c-NTP水平与认知功能受损呈正相关,与血清BDNF水平呈负相关(均P<0.05)。结论帕金森病患者血清MIF、尿AD7c-NTP水平与认知功能受损呈正相关,与血清BDNF水平呈负相关,患者血清MIF、尿AD7c-NTP水平越高,血清BDNF水平越低,患者认知功能受损越严重。可作为判断帕金森病患者认知功能受损程度的重要指标,为临床提供参考依据。
Objective To investigate the correlation between serum migration inhibitory factor(MIF),brain-derived neurotrophic factor(BDNF)and urine Alzheimer-associated neuronal thread protein(AD7c-NTP)expression levels and cognitive impairment in patients with Parkinson's dementia.Methods From February 2018 to February 2020,115 inpatients and outpatients with Parkinson's dementia in Ningde Hospital Affiliated to Fujian Medical University were enrolled as study group,meanwhile,another 118 healthy individual were enrolled as control group.Study group was further divided into three subgroups according to Mini-Mental State Examination(MMSE)scores,mild group,moderate group and severe group.Then the comparison of clinical data,fractional anisotropy(FA)and mean diffusivity(MD)in each region of interests,serum MIF,BDNF and urine AD7c-NTP levels was carried out within groups and subgroups.Results MMSE score of study group was significantly lower than that of control group(P<0.05).Serum MIF and urine AD7c-NTP levels of study group were higher than those of control group,and serum BDNF level was lower than that of control group(P<0.05).FA and MD values showed significant difference among three subgroups(P<0.05).Serum MIF level and urine AD7c-NTP levels among three subgroups were the highest in severe group,followed by moderate group and mild group,with significant difference(P<0.05).Serum BDNF level among three subgroups was the lowest in severe group,followed by moderate group and mild group,with significant difference(P<0.05).Serum MIF level and urine AD7c-NTP levels were positively correlated with degrees of cognitive impairment(P<0.05),and serum BDNF level was negatively correlated with degrees of cognitive impairment(P<0.05).Conclusion Degrees of cognitive impairment in patients with Parkinson's dementia are positively correlated with serum MIF and urine AD7c-NTP levels,and negatively correlated with serum BDNF level,so patients with elevated serum MIF and urine AD7c-NTP levels as well as decreased serum BDNF level suffer a more
作者
侯俊霞
叶林峰
欧鲤娴
黄艮彬
叶作东
黄维英
HOU Junxia;YE Linfeng;OU Lixian;HUANG Genbin;YE Zuodong;HUANG Weiying(Department of Neurology, Ningde Hospital Affiliated to Fujian Medical University, Ningde 352100, Fujian, China;Department of Laboratory, Ningde Hospital Affiliated to Fujian Medical University, Ningde 352100, Fujian, China;Department of Pharmacy, Ningde Hospital Affiliated to Fujian Medical University, Ningde 352100, Fujian, China)
出处
《西部医学》
2021年第11期1665-1669,1674,共6页
Medical Journal of West China
基金
福建省卫生计生委青年科研课题(2018-2-56)
福建医科大学启航基金(2017XQ1175)。
