摘要
目的评估细胞黏合素C(TNC)对冠心病(CHD)及冠状动脉粥样硬化严重程度的预测价值。方法纳入160例经冠状动脉造影的胸痛患者,根据造影结果,患者被分为两组:CHD组(n=90)和non-CHD组(n=70)。冠状动脉粥样硬化严重程度采用Gensini评分评价,并将CHD患者分为3组:低Gensini评分组(n=39)、中Gensini评分组(n=27)、高Gensini评分组(n=24)。比较各组血清TNC水平。Pearson相关性分析、多因素线性回归分析评估TNC与Gensini评分的相关性。ROC曲线分析TNC对冠心病及高Gensini评分患者的预测价值。结果CHD组血清TNC水平显著高于non-CHD组(P<0.001);高Gensini评分组血清TNC水平显著高于中Gensini评分组,中Gensini评分组TNC水平显著高于低Gensini评分组(P<0.001)。Pearson相关性分析、多因素线性回归分析显示,CHD组血清TNC水平与Gensini评分呈显著正相关(P<0.001)。ROC曲线分析显示,TNC预测CHD的曲线下面积(AUC)为0.811(95%CI:0.768~0.974),Cut-off值为11.94μg/L,灵敏度和特异度分别为83.5%和76.4%;TNC预测高Gensini评分患者的AUC为0.944(95%CI:0.816~0.989),Cut-off值为16.47μg/L,灵敏度和特异度分别为82.6%和78.4%。结论血清TNC水平与CHD患者Gensini评分明显相关,对CHD及冠状动脉粥样硬化严重程度有一定的预测价值。
Aim To evaluate the predictive value of tenascin-C(TNC)in coronary heart disease(CHD)and coronary atherosclerosis severity.Methods 160 patients with chest pain who had undergone coronary angiography were included.According to the results of the angiography,the patients were divided into two groups:CHD group(n=90)and non-CHD group(n=70).The coronary atherosclerosis severity was evaluated by Gensini score,and the CHD patients were divided into three groups:low Gensini score group(n=39),medium Gensini score group(n=27),high Gensini score group(n=24).The levels of serum TNC were compared in each group.Pearson correlation analysis and multivariate linear regression analysis were used to evaluate the correlation between TNC and Gensini score.The predictive value of TNC in patients with coronary heart disease and high Gensini score was analyzed by ROC curve.Results The level of serum TNC in CHD group was significantly higher than that in non-CHD group(P<0.001),the serum TNC level of high Gensini score group was significantly higher than that of medium Gensini score group,and the serum TNC level of medium Gensini score group was significantly higher than that of low Gensini score group(P<0.001).Pearson correlation analysis and multivariate linear regression analysis showed that there was a significant positive correlation between the serum TNC level and Gensini score in CHD group(P<0.001).ROC curve analysis showed that the area under curve(AUC)of TNC for predicting CHD was 0.811(95%CI:0.768-0.974),and the Cut-off value was 11.94μg/L,the sensi-tivity and specificity were 83.5%and 76.4%respectively.The AUC of TNC in predicting patients with high Gensini score was 0.944(95%CI:0.816-0.989),and the Cut-off value was 16.47μg/L,the sensitivity and specificity were 82.6%and 78.4%respectively.Conclusion Serum TNC level is significantly correlated with Gensini score of CHD patients,which has a certain predictive value for CHD and coronary atherosclerosis severity.
作者
付晶
凃星
FU Jing;TU Xing(Clinical Laboratory,Wuhan Hospital for the Prevention and Treatment of Occupational Diseases,Wuhan,Hubei 430000,China;Clinical Laboratory,Wuhan Third Hospital,Wuhan,Hubei 430060,China)
出处
《中国动脉硬化杂志》
CAS
2021年第12期1071-1076,共6页
Chinese Journal of Arteriosclerosis
