摘要
目的分析高血压患者β1-肾上腺素能受体(ADRB1)基因多态性及人血浆脂蛋白A2(Lp-PLA2)与冠状动脉狭窄程度的关系。方法选取2019年3月至2020年12月期间南京医科大学附属医院收治的高血压患者248例,按照冠脉造影检查是否出现冠心病(CHD)分为60例对照组(非冠心病组)和188例观察组(冠心病组),比较两组患者ADRB1基因多态性、Lp-PLA2水平与各项生化指标,Gensini评分评价冠状动脉狭窄程度,分析Lp-PLA2水平与Gensini评分的相关性并探讨Lp-PLA2水平对高血压患者CHD的诊断价值。结果两组的GLU、TG、TCL、LDL-C水平比较,差异无统计学意义(P>0.05),观察组的Lp-PLA2水平、Gensini评分高于对照组,差异有统计学意义(P<0.05);两组的ADRB1基因GG、CC、GC多态性频率分布比较,差异无统计学意义(P>0.05);随着动脉狭窄程度增加,Lp-PLA2水平、Gensini评分升高,差异有统计学意义(P<0.05),而ADRB1基因多态性的差异无统计学意义(P>0.05);Lp-PLA2水平与Gensini评分呈正相关(r=0.900,P<0.001);Lp-PLA2水平诊断高血压CHD的AUC值为0.967,95%CI为0.947~0.987,约登指数为0.837,灵敏度92.00%,特异性91.7%。结论 Lp-PLA2水平能够反映冠状动脉狭窄程度,具有诊断高血压CHD的价值,ADRB1基因多态性与冠状动脉狭窄程度无关联。
Objective To analyze the relationship between β1-adrenergic receptor(ADRB1)gene polymorphism and human plasma lipoprotein A2(Lp-PLA2)and the degree of coronary artery stenosis in patients with hypertension. Methods 248 hypertensive patients admitted to the Affiliated Hospital of Nanjing Medical University from March 2019 to December 2020 were selected,and divided them into 60 cases of the control group(non-coronary heart disease group)and 188 cases of the observation groups(coronary heart disease). The ADRB1 polymorphism,Lp-PLA2 level and biochemical indicators,Gensini score were compared between the two groups. The correlation of Lp-PLA2 level and Gensini score was evaluated. The diagnostic value of Lp-PLA2 level to CHD in hypertensive patients was explored. Results There was no statistically significant difference in the levels of GLU,TG,TCL,and LDL-C between the two groups(P>0.05). The Lp-PLA2 level and Gensini score in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05). There was no statistically significant difference in the frequency distribution of ADRB1 gene GG,CC,GC polymorphism between the two groups(P>0.05).As the degree of arterial stenosis increased,the level of Lp-PLA2 and Gensini score increased,and the difference was statistically significant(P<0.05),while the difference in ADRB1 gene polymorphism was not statistically significant(P>0.05). The Lp-PLA2-level was positively correlated with Gensini scores(r=0.900,P<0.001). The AUC value of Lp-PLA2 level in the diagnosis of hypertension CHD was 0.967,95% CI was 0.947 to0.987,Youden index was 0.837,the sensitivity was 92.00%,and the specificity was 91.7%. Conclusion The level of Lp-PLA2 can reflect the degree of coronary artery stenosis and has the value of diagnosing hypertensive CHD. The ADRB1 gene polymorphism is not related to the degree of coronary artery stenosis.
作者
毛文星
潘昌
郭雅洁
谢渡江
MAO Wenxing;PAN Chang;GUO Yajie;XIE Dujiang(Department of Cardiovascular Medicine,Nanjing Hospital(Nanjing First Hospital),Nanjing Medical University,Nanjing,Jiangsu,China,210006)
出处
《分子诊断与治疗杂志》
2021年第12期1994-1998,共5页
Journal of Molecular Diagnostics and Therapy
基金
南京市医学科技发展项目(YKK17106)。
