摘要
目的探讨膀胱内灌注无菌透明质酸钠溶液治疗膀胱过度活动症(OAB)的临床有效性和安全性。方法选取2016年6月至2019年12月在萍乡市人民医院门诊诊断为OAB的150例患者,按照随机数字表法分为无菌透明质酸钠组和索利那新组,每组各75例。无菌透明质酸钠组膀胱内灌注透明质酸钠,索利那新组口服琥珀酸索利那新,两组均治疗6个月。比较两组患者治疗前后的膀胱过度活动症症状评分(OABSS)、尿动力参数及不良反应情况。结果治疗6个月后,无菌透明质酸钠组的OABSS总评分及白天排尿次数、夜间排尿次数、尿急次数、急迫性尿失禁次数评分低于索利那新组,差异有统计学意义(P<0.05);无菌透明质酸钠组的初始尿意时膀胱容量、最大膀胱容量高于索利那新组,最大尿流率低于索利那新组,差异有统计学意义(P<0.05)。两组均未发生严重不良反应,两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论透明质酸钠膀胱灌注治疗OAB安全有效,可有效缓解OAB症状和改善膀胱功能,是一种可选的治疗方案。
Objective To explore the clinical effectiveness and safety of intravesical infusion of Sterile Sodium Hyaluronate Solution in the treatment of overactive bladder(OAB).Methods From June 2016 to December 2019,150 patients with OAB diagnosed in the Outpatient Department of Pingxiang People′s Hospital were selected and randomly divided into the Sterile Sodium Hyaluronate group and the Solinacine group according to random number table method,with 75 cases in each group.The Sterile Sodium Hyaluronate group was intravesically perfused with Sodium Hyaluronate,and the Solinacine group was orally administered with Solinacin Succinate.Both groups were treated for 6 months.The overactive bladder symptom score(OABSS),urodynamic parameters and adverse reactions were compared between the two groups before and after treatment.Results After 6 months of treatment,The total score of OABSS and the scores of diurnal urination,nocturnal urination,urgent urination and urgent urinary incontinence in the Sterile Sodium Hyaluronate group were lower than those in the Solinacine group,the differences were statistically significant(P<0.05).The volume at first desire and maximum cystometric capacity of the Sterile Sodium Hyaluronate group were higher than those of the Solinacine group,and the maximum urinary flow rate of the Sterile Sodium Hyaluronate group was lower than that of the Solinacine group,the differences were statistically significant(P<0.05).There were no serious adverse reactions between the two groups.There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium hyaluronate bladder perfusion is safe and effective in the treatment of OAB,which can effectively relieve OAB symptoms and improve bladder function.It is an optional treatment.
作者
康曦
张婷
王俊
胡海兵
谢诊莲
KANG Xi;ZHANG Ting;WANG Jun;HU Hai-bing;XIE Zhen-lian(Department of Urology,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China;Department of Spine Surgery,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China)
出处
《中国当代医药》
CAS
2021年第31期107-110,共4页
China Modern Medicine
基金
江西省萍乡市科学技术计划项目(2017NS026)。
