摘要
目的:探讨盐酸多奈哌齐对老年阿尔茨海默病患者的治疗效果及对简易精神状态检查量表(mini mental status examination,MMSE)评分等指标的影响。方法:选取2018年1月至2020年6月保定市第一中心医院收治的老年阿尔茨海默病患者100例作为观察对象,按照随机数字表法将其分为研究组和对照组,每组50例。对照组患者采用常规治疗,研究组患者在对照组的基础上联合盐酸多奈哌齐治疗。观察两组患者的治疗效果与不良事件发生情况,治疗前后的MMSE评分、日常生活活动(activity of daily living,ADL)评分和阿尔茨海默病病理行为评分量表(pathological behavior scale-Alzheimers disease,BEHAVE-AD)评分,氧化应激等相关血清指标。结果:与对照组总有效率(70.00%,35/50)相比,研究组患者的总有效率明显更高,为90.00%(45/50),差异有统计学意义(P<0.05)。治疗后,两组患者的MMSE评分、ADL评分和BEHAVE-AD评分均较治疗前明显改变;与对照组相比,研究组患者的MMSE评分、ADL评分明显升高,BEHAVE-AD评分明显降低,差异均有统计学意义(P<0.05)。治疗后,两组患者的SOD、MDA、DA和NGF水平较治疗前明显改善;与对照组相比,研究组患者的SOD、DA和NGF水平明显升高,MDA水平明显降低,差异均有统计学意义(P<0.05)。研究组、对照组患者不良事件发生率为12.00%(6/50)、8.00%(4/50),组间比较,差异无统计学意义(P>0.05)。结论:对于老年阿尔茨海默病患者,盐酸多奈哌齐联合常规治疗的效果较好,且安全性较好,还可有效改善患者的认知功能、生活能力和精神行为症状,临床应用价值较高。
OBJECTIVE:To explore the efficacy of donepezil hydrochloride in the treatment of elderly patients with Alzheimer’s disease and its effects on mini mental status examination(MMSE)score and other indicators.METHODS:Totally 110 elderly patients with Alzheimer’s disease admitted into Baoding First Central Hospital from Jan.2018 to Jun.2020 were extracted to be divided into the study group and the control group via the random number table,with 50 cases in each group.The control group received conventional treatment,and on this basis,the study group was given donepezil hydrochloride.The treatment efficacy and adverse drug events of two groups were observed.The MMSE score,activities of daily living(ADL)score and pathological behavior scale-Alzheimer’s disease(BEHAVE-AD),oxidative stress and other related serum indicators of two groups were compared before and after treatment.RESULTS:Compared with 70.00%(35/50)in the control group,the total effective rate in the study group was significantly higher,totally 90.00%(45/50),the difference was statistically significant(P<0.05).Compared with before treatment,MMSE score,ADL score and BEHAVE-AD score of two groups changed significantly after treatment.Compared with the control group,MMSE score and ADL score in the study group increased significantly,while BEHAVED-AD score decreased significantly,the differences were statistically significant(P<0.05).Compared with before treatment,the levels of SOD,MDA,DA and NGF of two groups were improved significantly;compared with the control group,the levels of SOD,DA and NGF in the study group increased significantly,while the level of MDA decreased significantly,with statistically significant difference(P<0.05).The incidence of adverse drug events in the study group and the control group was respectively 12.00%(6/50)and 8.00%(4/50),with no statistically significant difference between two groups(P>0.05).CONCLUSIONS:For elderly patients with Alzheimer’s disease,the efficacy of donepezil hydrochloride combined with conventional treatm
作者
刘璐
张潇潇
赵静
孟会红
刘永刚
LIU Lu;ZHANG Xiaoxiao;ZHAO Jing;MENG Huihong;LIU Yonggang(Dept.of Clinical Psychology,Baoding First Central Hospital,Hebei Baoding 071000,China;Dept.of Neurology,Baoding First Central Hospital,Hebei Baoding 071000,China)
出处
《中国医院用药评价与分析》
2021年第10期1188-1191,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省卫生健康委员会医学科学研究课题(No.20191232)。
